Karen L Svenson
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Explore the profile of Karen L Svenson including associated specialties, affiliations and a list of published articles.
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3717
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Recent Articles
1.
Mullis M, Wright K, Raj A, Gatti D, Reifsnyder P, Flurkey K, et al.
bioRxiv
. 2024 Nov;
PMID: 39605744
Lifespan is an integrative phenotype whose genetic architecture is likely to highlight multiple processes with high impact on health and aging. Here, we conduct a genetic meta-analysis of longevity in...
2.
Spielmann N, Miller G, Oprea T, Hsu C, Fobo G, Frishman G, et al.
Nat Cardiovasc Res
. 2024 Aug;
1(2):157-173.
PMID: 39195995
Clinical presentation of congenital heart disease is heterogeneous, making identification of the disease-causing genes and their genetic pathways and mechanisms of action challenging. By using in vivo electrocardiography, transthoracic echocardiography...
3.
Roy T, Bubier J, Dickson P, Wilcox T, Ndukum J, Clark J, et al.
Genes Brain Behav
. 2024 Jan;
:e12875.
PMID: 38164795
Substance use disorders are heritable disorders characterized by compulsive drug use, the biological mechanisms for which remain largely unknown. Genetic correlations reveal that predisposing drug-naïve phenotypes, including anxiety, depression, novelty...
4.
Roy T, Bubier J, Dickson P, Wilcox T, Ndukum J, Clark J, et al.
bioRxiv
. 2023 Jul;
PMID: 37503148
Substance use disorders (SUDs) are heritable disorders characterized by compulsive drug use, but the biological mechanisms driving addiction remain largely unknown. Genetic correlations reveal that predisposing drug-naïve phenotypes, including anxiety,...
5.
Svenson K, Krasinski S, Ellis M, Rosenthal N, Liu E, Fasman K
Dis Model Mech
. 2022 Oct;
15(10).
PMID: 36250972
In 2021, the National Institutes of Health Advisory Committee to the Director (ACD) announced recommendations to improve the reproducibility of biomedical research using animals. In response, The Jackson Laboratory faculty...
6.
Perez B, Bink M, Svenson K, Churchill G, Calus M
G3 (Bethesda)
. 2022 Sep;
12(11).
PMID: 36161485
Recent developments allowed generating multiple high-quality 'omics' data that could increase the predictive performance of genomic prediction for phenotypes and genetic merit in animals and plants. Here, we have assessed...
7.
Chick J, Munger S, Simecek P, Huttlin E, Choi K, Gatti D, et al.
Nature
. 2022 Jun;
606(7915):E16.
PMID: 35672473
No abstract available.
8.
Perez B, Bink M, Svenson K, Churchill G, Calus M
G3 (Bethesda)
. 2022 Feb;
12(4).
PMID: 35166767
We compared the performance of linear (GBLUP, BayesB, and elastic net) methods to a nonparametric tree-based ensemble (gradient boosting machine) method for genomic prediction of complex traits in mice. The...
9.
Keenan B, Galante R, Lian J, Zhang L, Guo X, Veatch O, et al.
Curr Biol
. 2021 Oct;
31(23):5238-5248.e7.
PMID: 34653361
Many aspects of sleep are heritable, but only a few sleep-regulating genes have been reported. Here, we leverage mouse models to identify and confirm a previously unreported gene affecting sleep...
10.
Long L, Svenson K, Mourino A, Michaud M, Fahey J, Waterman L, et al.
Lab Anim (NY)
. 2021 Jun;
50(7):185-195.
PMID: 34127866
Animal models play a critical role in establishing causal relationships between gut microbiota and disease. The laboratory mouse is widely used to study the role of microbes in various disorders;...