David B Parkinson
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Explore the profile of David B Parkinson including associated specialties, affiliations and a list of published articles.
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41
Citations
2119
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Recent Articles
1.
Dun X, Carr L, Woodley P, Barry R, Drake L, Mindos T, et al.
Cell Rep
. 2023 May;
42(5):112517.
PMID: 37148243
No abstract available.
2.
Laraba L, Hillson L, de Guibert J, Hewitt A, Jaques M, Tang T, et al.
Brain
. 2022 Sep;
146(4):1697-1713.
PMID: 36148553
Schwannoma tumours typically arise on the eighth cranial nerve and are mostly caused by loss of the tumour suppressor Merlin (NF2). There are no approved chemotherapies for these tumours and...
3.
Maze E, Agit B, Reeves S, Hilton D, Parkinson D, Laraba L, et al.
Cancer Res
. 2021 Dec;
82(2):235-247.
PMID: 34853069
Deficiency of the tumor suppressor Merlin causes development of schwannoma, meningioma, and ependymoma tumors, which can occur spontaneously or in the hereditary disease neurofibromatosis type 2 (NF2). Merlin mutations are...
4.
Li M, Banton M, Min Q, Parkinson D, Dun X
Front Cell Neurosci
. 2021 Nov;
15:688243.
PMID: 34744629
Following peripheral nerve injury, transcription factors upregulated in the distal nerve play essential roles in Schwann cell reprogramming, fibroblast activation and immune cell function to create a permissive distal nerve...
5.
Chen B, Banton M, Singh L, Parkinson D, Dun X
Front Cell Neurosci
. 2021 Apr;
15:624826.
PMID: 33828460
The advances in single-cell RNA sequencing technologies and the development of bioinformatics pipelines enable us to more accurately define the heterogeneity of cell types in a selected tissue. In this...
6.
Rafipay A, Dun X, Parkinson D, Erskine L, Vargesson N
Dev Dyn
. 2020 Dec;
250(9):1340-1357.
PMID: 33347679
Background: Slits (1-3) and their Robo (1-3) receptors play multiple non-neuronal roles in development, including in development of muscle, heart and mammary gland. Previous work has demonstrated expression of Slit...
7.
Chen B, Hu R, Min Q, Li Y, Parkinson D, Dun X
Front Cell Neurosci
. 2020 Aug;
14:237.
PMID: 32848626
The fibroblast growth factor (FGF) family polypeptides play key roles in promoting tissue regeneration and repair. FGF5 is strongly up-regulated in Schwann cells of the peripheral nervous system following injury;...
8.
Min Q, Parkinson D, Dun X
Glia
. 2020 Jul;
69(2):235-254.
PMID: 32697392
Schwann cells within the peripheral nervous system possess a remarkable regenerative potential. Current research shows that peripheral nerve-associated Schwann cells possess the capacity to promote repair of multiple tissues including...
9.
Palomo-Irigoyen M, Perez-Andres E, Iruarrizaga-Lejarreta M, Barreira-Manrique A, Tamayo-Caro M, Vila-Vecilla L, et al.
J Clin Invest
. 2020 Apr;
130(7):3848-3864.
PMID: 32315290
Cancer cells can develop a strong addiction to discrete molecular regulators, which control the aberrant gene expression programs that drive and maintain the cancer phenotype. Here, we report the identification...
10.
Chen B, Chen Q, Parkinson D, Dun X
Front Mol Neurosci
. 2020 Jan;
12:308.
PMID: 31920539
While it is proposed that interaction between Schwann cells and axons is key for successful nerve regeneration, the behavior of Schwann cells migrating into a nerve gap following a transection...