David Aharony
Overview
Explore the profile of David Aharony including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
105
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Brown D, Bernstein P, Wu Y, Urbanek R, Becker C, Throner S, et al.
ACS Med Chem Lett
. 2014 Jun;
4(1):46-51.
PMID: 24900562
Herein, we describe the discovery of inhibitors of norepinephrine (NET) and dopamine (DAT) transporters with reduced activity relative to serotonin transporters (SERT). Two compounds, 8b and 21a, along with nomifensine...
2.
Gordon J, Edwards P, Elmore C, Lazor L, Paschetto K, Bostwick R, et al.
Eur J Pharmacol
. 2010 Sep;
649(1-3):59-63.
PMID: 20854803
The peptide corticotropin-releasing factor (CRF) binds to the CRF₁ receptor via a two-domain mechanism such that the extracellular domain (ECD) of the receptor captures the CRF's C-terminus to facilitate the...
3.
Yu J, Mathisen D, Burdette D, Brown D, Becker C, Aharony D
Drug Metab Dispos
. 2009 Oct;
38(1):46-60.
PMID: 19812352
8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (nomifensine), an antidepressant drug, was withdrawn from the market because of increased incidence of hemolytic anemia, as well as kidney and liver toxicity. Although the nature of the...
4.
Edwards P, Albert J, Sylvester M, Aharony D, Andisik D, Callaghan O, et al.
J Med Chem
. 2007 Nov;
50(24):5912-25.
PMID: 17985862
Fragment-based lead generation has led to the discovery of a novel series of cyclic amidine-based inhibitors of beta-secretase (BACE-1). Initial fragment hits with an isocytosine core having millimolar potency were...
5.
Congreve M, Aharony D, Albert J, Callaghan O, Campbell J, Carr R, et al.
J Med Chem
. 2007 Feb;
50(6):1124-32.
PMID: 17315857
Fragment-based lead discovery has been successfully applied to the aspartyl protease enzyme beta-secretase (BACE-1). Fragment hits that contained an aminopyridine motif binding to the two catalytic aspartic acid residues in...
6.
Ohnmacht C, Albert J, Bernstein P, Rumsey W, Masek B, Dembofsky B, et al.
Bioorg Med Chem
. 2004 Apr;
12(10):2653-69.
PMID: 15110847
Previously we reported on the synthesis and properties of a series of highly potent piperidinyl 2-subsituted-3-cyano-1-naphthamide NK1 antagonists that includes 3 and 4. Here we report our efforts to alleviate...
7.
Albert J, Ohnmacht C, Bernstein P, Rumsey W, Aharony D, Alelyunas Y, et al.
J Med Chem
. 2004 Jan;
47(3):519-29.
PMID: 14736234
We have previously described a series of antagonists that showed high potency and selectivity for the NK(1) receptor. However, these compounds also had the undesirable property of existing as a...
8.
Tian G, Ghanekar S, Aharony D, Shenvi A, Jacobs R, Liu X, et al.
J Biol Chem
. 2003 Apr;
278(31):28968-75.
PMID: 12719412
Transition state analogs pepstatin methylester (PME) and L685458 have been shown to inhibit gamma-secretase non-competitively (Tian, G., Sobotka-Briner, C., Zysk, J., Liu, X., Birr, C., Sylvester, M. A., Edwards, P....
9.
Scott C, Sobotka-Briner C, Wilkins D, Jacobs R, Folmer J, Frazee W, et al.
J Pharmacol Exp Ther
. 2002 Dec;
304(1):433-40.
PMID: 12490620
Caspase-3 is an intracellular cysteine protease, activated as part of the apoptotic response to cell injury. Its interest as a therapeutic target has led many to pursue the development of...
10.
Albert J, Aharony D, Andisik D, Barthlow H, Bernstein P, Bialecki R, et al.
J Med Chem
. 2002 Aug;
45(18):3972-83.
PMID: 12190319
Through optimization of compounds based on the dual NK(1)/NK(2) antagonist ZD6021, it was found that alteration of two key regions could modulate the balance of NK(1) and NK(2) potency. Substitution...