Owen Callaghan
Overview
Explore the profile of Owen Callaghan including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
165
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0
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Recent Articles
1.
Murray C, Carr M, Callaghan O, Chessari G, Congreve M, Cowan S, et al.
J Med Chem
. 2010 Aug;
53(16):5942-55.
PMID: 20718493
Inhibitors of the chaperone Hsp90 are potentially useful as chemotherapeutic agents in cancer. This paper describes an application of fragment screening to Hsp90 using a combination of NMR and high...
2.
Frederickson M, Callaghan O, Chessari G, Congreve M, Cowan S, Matthews J, et al.
J Med Chem
. 2008 Jan;
51(2):183-6.
PMID: 18163548
Fragment-based lead discovery has been applied to urokinase-type plasminogen activator (uPA). The (R)-enantiomer of the orally active drug mexiletine 5 (a fragment hit from X-ray crystallographic screening) was the chemical...
3.
Edwards P, Albert J, Sylvester M, Aharony D, Andisik D, Callaghan O, et al.
J Med Chem
. 2007 Nov;
50(24):5912-25.
PMID: 17985862
Fragment-based lead generation has led to the discovery of a novel series of cyclic amidine-based inhibitors of beta-secretase (BACE-1). Initial fragment hits with an isocytosine core having millimolar potency were...
4.
Congreve M, Aharony D, Albert J, Callaghan O, Campbell J, Carr R, et al.
J Med Chem
. 2007 Feb;
50(6):1124-32.
PMID: 17315857
Fragment-based lead discovery has been successfully applied to the aspartyl protease enzyme beta-secretase (BACE-1). Fragment hits that contained an aminopyridine motif binding to the two catalytic aspartic acid residues in...
5.
Murray C, Callaghan O, Chessari G, Cleasby A, Congreve M, Frederickson M, et al.
J Med Chem
. 2007 Feb;
50(6):1116-23.
PMID: 17315856
This paper describes an application of fragment screening to the aspartyl protease enzyme, beta-secretase (BACE-1), using high throughput X-ray crystallography. Three distinct chemotypes were identified by X-ray crystallography as binding...