David A Slatter
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Explore the profile of David A Slatter including associated specialties, affiliations and a list of published articles.
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25
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629
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Recent Articles
11.
Ying Chow W, Bihan D, Forman C, Slatter D, Reid D, Wales D, et al.
Sci Rep
. 2015 Jul;
5:12556.
PMID: 26220399
Collagens, the most abundant proteins in mammals, are defined by their triple-helical structures and distinctive Gly-Xaa-Yaa repeating sequence, where Xaa is often proline and Yaa, hydroxyproline (Hyp/O). It is known...
12.
Howes J, Bihan D, Slatter D, Hamaia S, Packman L, Knauper V, et al.
J Biol Chem
. 2014 Jul;
289(35):24091-101.
PMID: 25008319
Remodeling of collagen by matrix metalloproteinases (MMPs) is crucial to tissue homeostasis and repair. MMP-13 is a collagenase with a substrate preference for collagen II over collagens I and III....
13.
Ying Chow W, Rajan R, Muller K, Reid D, Skepper J, Wong W, et al.
Science
. 2014 May;
344(6185):742-6.
PMID: 24833391
Nuclear magnetic resonance (NMR) spectroscopy is useful to determine molecular structure in tissues grown in vitro only if their fidelity, relative to native tissue, can be established. Here, we use...
14.
Aldrovandi M, Hammond V, Podmore H, Hornshaw M, Clark S, Marnett L, et al.
J Lipid Res
. 2013 Jul;
54(11):3085-97.
PMID: 23883581
Oxidized phospholipids (oxPLs) generated nonenzymatically display pleiotropic biological actions in inflammation. Their generation by cellular cyclooxygenases (COXs) is currently unknown. To determine whether platelets generate prostaglandin (PG)-containing oxPLs, then characterize...
15.
Slatter D, Bihan D, Jarvis G, Stone R, Pugh N, Giddu S, et al.
Peptides
. 2012 May;
36(1):86-93.
PMID: 22555281
Recently, the ability of polymeric collagen-like peptides to regulate cell behavior has generated great interest. A triple-helical peptide known as collagen-related peptide (CRP) contains the sequence (Gly-Pro-Hyp)(10). With Gly-Pro-Cys triplets...
16.
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice
Barrow A, Raynal N, Andersen T, Slatter D, Bihan D, Pugh N, et al.
J Clin Invest
. 2011 Aug;
121(9):3505-16.
PMID: 21841309
Osteoclasts are terminally differentiated leukocytes that erode the mineralized bone matrix. Osteoclastogenesis requires costimulatory receptor signaling through adaptors containing immunoreceptor tyrosine-based activation motifs (ITAMs), such as Fc receptor common γ...
17.
Slatter D, Bihan D, Farndale R
Biomaterials
. 2011 Jun;
32(27):6621-32.
PMID: 21663955
Collagen is the fundamental structural protein, comprising 25-35% of the total body protein, its rod-like triple helix providing support in many tissues. Our laboratory has synthesised 113 Toolkit peptides, each...
18.
Erat M, Slatter D, Lowe E, Millard C, Farndale R, Campbell I, et al.
Proc Natl Acad Sci U S A
. 2009 Mar;
106(11):4195-200.
PMID: 19251642
Collagen and fibronectin are major components of vertebrate extracellular matrices. Their association and distribution control the development and properties of diverse tissues, but thus far no structural information has been...
19.
Slatter D, Avery N, Bailey A
Int J Biochem Cell Biol
. 2008 Apr;
40(10):2253-63.
PMID: 18436470
To assess the impact collagen structures may have on glycation, the effects of glucose upon bovine serum albumin, guinea pig skin collagen, rat tail tendon and monomeric collagen were compared...
20.
Asara J, Garavelli J, Slatter D, Schweitzer M, Freimark L, Phillips M, et al.
Science
. 2007 Sep;
317(5843):1324-5.
PMID: 17823333
No abstract available.