David A Slatter
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Explore the profile of David A Slatter including associated specialties, affiliations and a list of published articles.
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25
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629
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Recent Articles
1.
Rosas M, Slatter D, Obaji S, Webber J, Alvarez-Jarreta J, Thomas C, et al.
PLoS One
. 2020 Oct;
15(10):e0240189.
PMID: 33031441
Tissue factor (TF) is critical for the activation of blood coagulation. TF function is regulated by the amount of externalised phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the surface of the...
2.
Meckelmann S, Hawksworth J, White D, Andrews R, Rodrigues P, OConnor A, et al.
Circ Genom Precis Med
. 2020 May;
13(3):e002806.
PMID: 32396387
Background: Common chromosome 9p21 single nucleotide polymorphisms (SNPs) increase coronary heart disease risk, independent of traditional lipid risk factors. However, lipids comprise large numbers of structurally related molecules not measured...
3.
Allen-Redpath K, Aldrovandi M, Lauder S, Gketsopoulou A, Tyrrell V, Slatter D, et al.
Proc Natl Acad Sci U S A
. 2019 Apr;
116(16):8038-8047.
PMID: 30944221
Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease with high mortality and limited treatment options. How blood lipids regulate AAA development is unknown. Here lipidomics and genetic models demonstrate...
4.
Chow W, Forman C, Bihan D, Puszkarska A, Rajan R, Reid D, et al.
Sci Rep
. 2018 Sep;
8(1):13809.
PMID: 30218106
Fibrillar collagens have mechanical and biological roles, providing tissues with both tensile strength and cell binding sites which allow molecular interactions with cell-surface receptors such as integrins. A key question...
5.
Slatter D, Percy C, Allen-Redpath K, Gajsiewicz J, Brooks N, Clayton A, et al.
JCI Insight
. 2018 Mar;
3(6).
PMID: 29563336
Hemostatic defects are treated using coagulation factors; however, clot formation also requires a procoagulant phospholipid (PL) surface. Here, we show that innate immune cell-derived enzymatically oxidized phospholipids (eoxPL) termed hydroxyeicosatetraenoic...
6.
Lauder S, Allen-Redpath K, Slatter D, Aldrovandi M, OConnor A, Farewell D, et al.
Sci Signal
. 2017 Nov;
10(507).
PMID: 29184033
Blood coagulation functions as part of the innate immune system by preventing bacterial invasion, and it is critical to stopping blood loss (hemostasis). Coagulation involves the external membrane surface of...
7.
OConnor A, Brasher C, Slatter D, Meckelmann S, Hawksworth J, Allen S, et al.
JCI Insight
. 2017 Apr;
2(7):e91634.
PMID: 28405621
Accurate and high-quality curation of lipidomic datasets generated from plasma, cells, or tissues is becoming essential for cell biology investigations and biomarker discovery for personalized medicine. However, a major challenge...
8.
Aldrovandi M, Hinz C, Lauder S, Podmore H, Hornshaw M, Slatter D, et al.
Redox Biol
. 2017 Feb;
11:663-672.
PMID: 28160743
Activated platelets generate an eicosanoid proposed to be 8-hydroxy-9,10-dioxolane A3 (DXA). Herein, we demonstrate that significant amounts of DXA are rapidly attached to phosphatidylethanolamine (PE) forming four esterified eicosanoids, 16:0p,...
9.
Slatter D, Aldrovandi M, OConnor A, Allen S, Brasher C, Murphy R, et al.
Cell Metab
. 2016 May;
23(5):930-44.
PMID: 27133131
Human platelets acutely increase mitochondrial energy generation following stimulation. Herein, a lipidomic circuit was uncovered whereby the substrates for this are exclusively provided by cPLA2, including multiple fatty acids and...
10.
Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid
Hinz C, Aldrovandi M, Uhlson C, Marnett L, Longhurst H, Warner T, et al.
J Biol Chem
. 2016 Apr;
291(26):13448-64.
PMID: 27129261
Eicosanoids are important mediators of fever, pain, and inflammation that modulate cell signaling during acute and chronic disease. We show by using lipidomics that thrombin-activated human platelets generate a new...