David A Hume
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Explore the profile of David A Hume including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Waddell L, Wu Z, Sauter K, Hope J, Hume D
Vet Immunol Immunopathol
. 2023 Nov;
266:110681.
PMID: 37992576
Macrophage colony-stimulating factor (CSF1) controls the proliferation and differentiation of cells of the mononuclear phagocyte system through binding to the receptor CSF1R. The expression and function of CSF1 has been...
12.
Huang S, Carter-Cusack D, Maxwell E, Patkar O, Irvine K, Hume D
Methods Mol Biol
. 2023 Aug;
2713:99-115.
PMID: 37639117
Macrophages contribute to many aspects of development and homeostasis, innate and acquired immunity, immunopathology, and tissue repair. Every tissue contains an abundant resident macrophage population. Inflammatory stimuli promote the recruitment...
13.
Hume D, Millard S, Pettit A
Blood
. 2023 Aug;
142(16):1339-1347.
PMID: 37595274
In this spotlight, we review technical issues that compromise single-cell analysis of tissue macrophages, including limited and unrepresentative yields, fragmentation and generation of remnants, and activation during tissue disaggregation. These...
14.
Hume D, Teakle N, Keshvari S, Irvine K
J Leukoc Biol
. 2023 May;
114(5):421-433.
PMID: 37167456
Macrophages are an abundant cell population in the placenta and developing embryo and appear to be involved in processes of vascularization, morphogenesis, organogenesis, and hematopoiesis. The proliferation, differentiation, and survival...
15.
Sehgal A, Carter-Cusack D, Keshvari S, Patkar O, Huang S, Summers K, et al.
Eur J Immunol
. 2023 Apr;
53(8):e2250312.
PMID: 37059596
Homozygous null mutation of the Csf1r gene (Csf1rko) in rats leads to the loss of most tissue macrophage populations and pleiotropic impacts on postnatal growth and organ maturation, leading to...
16.
Hume D
Eur J Immunol
. 2023 Apr;
53(6):e2250242.
PMID: 37016273
The mononuclear phagocyte system (MPS) was defined in the early 1970s as a family of cells including progenitors, monocytes in the circulation, and resident tissue macrophages. They arise during development...
17.
Grootveld A, Kyaw W, Panova V, Lau A, Ashwin E, Seuzaret G, et al.
Cell
. 2023 Mar;
186(6):1144-1161.e18.
PMID: 36868219
Germinal centers (GCs) that form within lymphoid follicles during antibody responses are sites of massive cell death. Tingible body macrophages (TBMs) are tasked with apoptotic cell clearance to prevent secondary...
18.
Chundru V, Marioni R, Prendergast J, Lin T, Beveridge A, Martin N, et al.
Hum Mol Genet
. 2023 Feb;
32(11):1912-1921.
PMID: 36790133
Testing the effect of rare variants on phenotypic variation is difficult due to the need for extremely large cohorts to identify associated variants given expected effect sizes. An alternative approach...
19.
Summers K, Bush S, Davis M, Hume D, Keshvari S, West J
Mol Genet Metab
. 2023 Jan;
138(1):106979.
PMID: 36630758
Fibrillin-1 is a major component of the extracellular microfibrils, where it interacts with other extracellular matrix proteins to provide elasticity to connective tissues, and regulates the bioavailability of TGFβ family...
20.
Ferrari-Cestari M, Okano S, Patel P, Horsfall L, Keshvari S, Hume D, et al.
Dig Dis
. 2022 Nov;
41(3):439-446.
PMID: 36327947
Background: Non-alcoholic fatty liver disease (NAFLD) is caused by ectopic fat accumulation in the liver as a consequence of metabolic perturbations associated with obesity, type 2 diabetes, dyslipidemia, and insulin...