David A F Loebel
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Explore the profile of David A F Loebel including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Loebel D, Hor A, Bildsoe H, Tam P
PLoS One
. 2014 Jun;
9(6):e98945.
PMID: 24893291
Twist1 encodes a transcription factor that plays a vital role in limb development. We have used a tamoxifen-inducible Cre transgene, Ubc-CreERT2, to generate time-specific deletions of Twist1 by inducing Cre...
12.
Loebel D, Radziewic T, Power M, Studdert J, Tam P
Methods Mol Biol
. 2013 Dec;
1092:119-42.
PMID: 24318817
We are using knockdown of gene expression in mouse embryos by constitutive expression of small hairpin (sh)RNAs as a means of observing loss-of-function phenotypes more rapidly than gene targeting. Plasmid...
13.
Kojima Y, Kaufman-Francis K, Studdert J, Steiner K, Power M, Loebel D, et al.
Cell Stem Cell
. 2013 Oct;
14(1):107-20.
PMID: 24139757
Mouse epiblast stem cells (EpiSCs) can be derived from a wide range of developmental stages. To characterize and compare EpiSCs with different origins, we derived a series of EpiSC lines...
14.
Bildsoe H, Loebel D, Jones V, Hor A, Braithwaite A, Chen Y, et al.
Dev Biol
. 2012 Dec;
374(2):295-307.
PMID: 23261931
The basic helix-loop-helix transcription factor Twist1 is a key regulator of craniofacial development. Twist1-null mouse embryos exhibit failure of cephalic neural tube closure and abnormal head development and die at...
15.
Loebel D, Tam P
Small GTPases
. 2012 Jun;
3(1):40-4.
PMID: 22714416
The embryonic foregut of the mouse embryo is lined by a layer of endoderm cells whose architecture changes during development. The transition from a squamous to columnar epithelial morphology is...
16.
Loebel D, Hor A, Bildsoe H, Jones V, Chen Y, Behringer R, et al.
Dev Biol
. 2011 Dec;
362(2):132-40.
PMID: 22178153
Development of the mouse forelimb bud depends on normal Twist1 activity. Global loss of Twist1 function before limb bud formation stops limb development and loss of Twist1 throughout the mesenchyme...
17.
Loebel D, Studdert J, Power M, Radziewic T, Jones V, Coultas L, et al.
Development
. 2011 Sep;
138(20):4511-22.
PMID: 21903671
Rhou encodes a Cdc42-related atypical Rho GTPase that influences actin organization in cultured cells. In mouse embryos at early-somite to early-organogenesis stages, Rhou is expressed in the columnar endoderm epithelium...
18.
Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos
Pfister S, Jones V, Power M, Truisi G, Khoo P, Steiner K, et al.
Int J Dev Biol
. 2011 Feb;
55(1):45-58.
PMID: 21305474
Sox17 is a transcription factor that is required for maintenance of the definitive endoderm in mouse embryos. By expression profiling of wild-type and mutant embryos and Sox17-overexpressing hepatoma cells, we...
19.
Bildsoe H, Loebel D, Jones V, Chen Y, Behringer R, Tam P
Dev Biol
. 2009 May;
331(2):176-88.
PMID: 19414008
Using a Cre-mediated conditional deletion approach, we have dissected the function of Twist1 in the morphogenesis of the craniofacial skeleton. Loss of Twist1 in neural crest cells and their derivatives...
20.
Tam P, Loebel D
Cell
. 2009 May;
137(3):398-400.
PMID: 19410535
Male germ cells are induced to form from the epiblast of the mouse embryo by a combination of WNT and bone morphogenetic protein signals. Ohinata et al. (2009) now clarify...