Patrick P L Tam
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Explore the profile of Patrick P L Tam including associated specialties, affiliations and a list of published articles.
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158
Citations
5168
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Recent Articles
1.
Shen S, Werner T, Lukowski S, Andersen S, Sun Y, Shim W, et al.
Nat Commun
. 2025 Feb;
16(1):1356.
PMID: 39904980
Pluripotent stem cells provide a scalable approach to analyse molecular regulation of cell differentiation across developmental lineages. Here, we engineer barcoded induced pluripotent stem cells to generate an atlas of...
2.
Tam P, Masamsetti P
Cells Dev
. 2025 Jan;
:203999.
PMID: 39880304
Induction of the neural ectoderm and the patterning of embryonic brain are the requisite organizing activity for head formation. Studies of loss-of-function mouse mutants that displayed a head truncation phenotype...
3.
Clark A, Goolam M, Hanna J, Long K, Nicol D, Petropoulos S, et al.
Development
. 2024 Sep;
151(17).
PMID: 39279534
In the companion Perspective 'Past and future of human developmental biology' (Hopwood, 2024), historian Nick Hopwood proposes that the field of human developmental biology has gone through periods of attention...
4.
Chen C, Lee S, Zyner K, Fernando M, Nemeruck V, Wong E, et al.
Cell Rep
. 2024 May;
43(5):114219.
PMID: 38748874
Defining the molecular networks orchestrating human brain formation is crucial for understanding neurodevelopment and neurological disorders. Challenges in acquiring early brain tissue have incentivized the use of three-dimensional human pluripotent...
5.
Wu Z, Shen S, Mizikovsky D, Cao Y, Naval-Sanchez M, Tan S, et al.
Dev Cell
. 2024 Feb;
59(6):705-722.e8.
PMID: 38354738
Wnt signaling is a critical determinant of cell lineage development. This study used Wnt dose-dependent induction programs to gain insights into molecular regulation of stem cell differentiation. We performed single-cell...
6.
Kim H, Wang K, Chen C, Lin Y, Tam P, Lin D, et al.
Nat Comput Sci
. 2024 Jan;
1(12):784-790.
PMID: 38217190
The use of single-cell RNA-sequencing (scRNA-seq) allows observation of different cells at multi-tiered complexity in the same microenvironment. To get insights into cell identity using scRNA-seq data, we present Cepo,...
7.
McMahon R, Masamsetti V, Tam P
Methods Mol Biol
. 2023 Dec;
2746:165-177.
PMID: 38070089
Analyzing the impact of genetic mutations on early neurogenesis of mammalian embryos in conventional mouse mutant models is laborious and time-consuming. To overcome these constraints and to fast-track the phenotypic...
8.
Wang R, Yang X, Chen J, Zhang L, Griffiths J, Cui G, et al.
Nat Commun
. 2023 Sep;
14(1):5675.
PMID: 37709743
Understanding of the molecular drivers of lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge of the dynamic molecular trajectories of cell lineages across a series...
9.
Masamsetti V, Tam P
Cell Rep Methods
. 2023 Sep;
3(8):100575.
PMID: 37671029
Iwatsuki and colleagues have generated self-renewing pluripotent stem cells from the pre-gastrulation epiblast of the rat embryo and from other cellular sources: rat embryonic stem cells (rESCs) and epiblast-like cells...
10.
Rugg-Gunn P, Moris N, Tam P
Development
. 2023 Jun;
150(11).
PMID: 37260362
Recent years have seen exciting progress across human embryo research, including new methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation, mapping lineage trajectories, and experimenting on stem cell-based...