David A Bernlohr
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Explore the profile of David A Bernlohr including associated specialties, affiliations and a list of published articles.
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124
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4228
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Recent Articles
11.
Chen D, Wirth K, Kizy S, Muretta J, Markowski T, Yong P, et al.
Mol Cancer Res
. 2023 Apr;
21(8):836-848.
PMID: 37115197
Implications: These results suggest desmosomal proteins, and in particular desmoglein 2, may function as receptors of eFABP4 and provide new insight into the development and progression of obesity-associated cancers.
12.
Olivieri C, Walker C, Veliparambil Subrahmanian M, Porcelli F, Taylor S, Bernlohr D, et al.
FEBS Lett
. 2023 Mar;
597(8):1055-1072.
PMID: 36892429
The cAMP-dependent protein kinase A (PKA) is the archetypical eukaryotic kinase. The catalytic subunit (PKA-C) structure is highly conserved among the AGC-kinase family. PKA-C is a bilobal enzyme with a...
13.
So S, Nixon J, Bernlohr D, Butterick T
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36834799
Microglial fatty-acid binding protein 4 (FABP4) is a regulator of neuroinflammation. We hypothesized that the link between lipid metabolism and inflammation indicates a role for FABP4 in regulating high fat...
14.
Narasimhan A, Flores R, Camell C, Bernlohr D, Robbins P, Niedernhofer L
Curr Diab Rep
. 2022 Oct;
22(11):537-548.
PMID: 36239841
Purpose Of Review: Obesity has increased worldwide recently and represents a major global health challenge. This review focuses on the obesity-associated cellular senescence in various organs and the role of...
15.
Olivieri C, Li G, Wang Y, V S M, Walker C, Kim J, et al.
Sci Adv
. 2022 Jul;
8(30):eabo0696.
PMID: 35905186
ATP-competitive inhibitors are currently the largest class of clinically approved drugs for protein kinases. By targeting the ATP-binding pocket, these compounds block the catalytic activity, preventing substrate phosphorylation. A problem...
16.
Hertzel A, Yong J, Chen X, Bernlohr D
Endocrinology
. 2022 Jun;
163(8).
PMID: 35752995
Immune cells infiltrate adipose tissue as a function of age, sex, and diet, leading to a variety of regulatory processes linked to metabolic disease and dysfunction. Cytokines and chemokines produced...
17.
Shinoda S, Nakamura N, Roach B, Bernlohr D, Ikramuddin S, Yamamoto M
Biomedicines
. 2022 Jun;
10(6).
PMID: 35740306
More than 30% of people in the United States (US) are classified as obese, and over 50% are considered significantly overweight. Importantly, obesity is a risk factor not only for...
18.
So S, Fleming K, Duffy C, Nixon J, Bernlohr D, Butterick T
Int J Mol Sci
. 2022 Apr;
23(8).
PMID: 35457171
The microglial fatty-acid-binding protein 4-uncoupling protein 2 (FABP4-UCP2) axis is a key regulator of neuroinflammation in high-fat-diet (HFD)-fed animals, indicating a role for FABP4 in brain immune response. We hypothesized...
19.
Huang Y, Yong P, Dickey D, Vora S, Wu H, Bernlohr D
Endocrinology
. 2022 Feb;
163(4).
PMID: 35136993
Obesity-linked diabetes is associated with accumulation of proinflammatory macrophages into adipose tissue leading to inflammasome activation and pyroptotic secretion of interleukin (IL)-1β and IL-18. Targeting fatty acid binding protein 4...
20.
Wirth K, Shinoda S, Sato-Dahlman M, Dickey D, Bernlohr D, Ikramuddin S, et al.
Surg Obes Relat Dis
. 2022 Jan;
18(4):485-493.
PMID: 34998697
Background: Obesity and diabetes are associated with an increased incidence of pancreatic cancer. Fatty acid binding protein 4 (FABP4), noted to be higher in patients with severe obesity, is linked...