Daryl E Klein
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Explore the profile of Daryl E Klein including associated specialties, affiliations and a list of published articles.
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18
Citations
625
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Recent Articles
1.
Zhang J, Tsutsui Y, Li H, Li T, Wang Y, Laraki S, et al.
Nat Commun
. 2025 Jan;
16(1):808.
PMID: 39827240
Sevenless, the Drosophila homologue of ROS1 (University of Rochester Sarcoma) (herein, dROS1) is a receptor tyrosine kinase (RTK) essential for the differentiation of Drosophila R7 photoreceptor cells. Activation of dROS1...
2.
Wang Y, Zhang Y, Li W, Salovska B, Zhang J, Li T, et al.
Mol Cell
. 2024 Dec;
85(1):166-176.e5.
PMID: 39642883
The rare γ-aminobutyric acid type-A receptor (GABAR) subunit π (GABRP) is highly expressed in certain cancers, where it stimulates growth through extracellular-regulated kinase (ERK) signaling by an uncharacterized pathway. To...
3.
Perez-Pepe M, Desotell A, Li H, Li W, Han B, Lin Q, et al.
Sci Adv
. 2023 May;
9(19):eade7500.
PMID: 37163588
A fundamental feature of cell signaling is the conversion of extracellular signals into adaptive transcriptional responses. The role of RNA modifications in this process is poorly understood. The small nuclear...
4.
Martin-Rufino J, Castano N, Pang M, Grody E, Joubran S, Caulier A, et al.
Cell
. 2023 May;
186(11):2456-2474.e24.
PMID: 37137305
Systematic evaluation of the impact of genetic variants is critical for the study and treatment of human physiology and disease. While specific mutations can be introduced by genome engineering, we...
5.
Li T, Stayrook S, Tsutsui Y, Zhang J, Wang Y, Li H, et al.
Nature
. 2021 Nov;
600(7887):148-152.
PMID: 34819665
The proto-oncogene ALK encodes anaplastic lymphoma kinase, a receptor tyrosine kinase that is expressed primarily in the developing nervous system. After development, ALK activity is associated with learning and memory...
6.
Bao E, Nandakumar S, Liao X, Bick A, Karjalainen J, Tabaka M, et al.
Nature
. 2020 Oct;
586(7831):769-775.
PMID: 33057200
Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells...
7.
Kiyatkin A, van Alderwerelt van Rosenburgh I, Klein D, Lemmon M
Sci Signal
. 2020 Aug;
13(645).
PMID: 32817373
In responses to activation of receptor tyrosine kinases (RTKs), crucial cell fate decisions depend on the duration and dynamics of ERK signaling. In PC12 cells, epidermal growth factor (EGF) induces...
8.
Verboon J, Mahmut D, Kim A, Nakamura M, Abdulhay N, Nandakumar S, et al.
J Clin Immunol
. 2020 Apr;
40(4):554-566.
PMID: 32303876
Studies of genetic blood disorders have advanced our understanding of the intrinsic regulation of hematopoiesis. However, such genetic studies have only yielded limited insights into how interactions between hematopoietic cells...
9.
Klein D
Biochem J
. 2017 Sep;
474(18):3087-3088.
PMID: 28860336
Inhibiting receptor tyrosine kinases has been a cornerstone of cancer therapeutics for decades. Treatment strategies largely involve small-molecule kinase inhibitors and monoclonal antibodies. For receptors activated by constitutively dimeric ligands,...
10.
Kim A, Ulirsch J, Wilmes S, Unal E, Moraga I, Karakukcu M, et al.
Cell
. 2017 Mar;
168(6):1053-1064.e15.
PMID: 28283061
Cytokines are classically thought to stimulate downstream signaling pathways through monotonic activation of receptors. We describe a severe anemia resulting from a homozygous mutation (R150Q) in the cytokine erythropoietin (EPO)....