Daryl E Klein
Overview
Explore the profile of Daryl E Klein including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
625
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Recent Articles
11.
Jenni S, Goyal Y, von Grotthuss M, Shvartsman S, Klein D
Mol Cell
. 2015 Dec;
60(6):941-52.
PMID: 26698662
In insects, brain-derived Prothoracicotropic hormone (PTTH) activates the receptor tyrosine kinase (RTK) Torso to initiate metamorphosis through the release of ecdysone. We have determined the crystal structure of silkworm PTTH...
12.
Chao L, Klein D, Schmidt A, Pena J, Harrison S
Elife
. 2015 May;
4.
PMID: 25984968
No abstract available.
13.
Chao L, Klein D, Schmidt A, Pena J, Harrison S
Elife
. 2014 Dec;
3:e04389.
PMID: 25479384
The West Nile Virus (WNV) envelope protein, E, promotes membrane fusion during viral cell entry by undergoing a low-pH triggered conformational reorganization. We have examined the mechanism of WNV fusion...
14.
Klein D, Choi J, Harrison S
J Virol
. 2012 Dec;
87(4):2287-93.
PMID: 23236058
The final stages of dengue virus fusion are thought to occur when the membrane-proximal stem drives the transmembrane anchor of the viral envelope protein (E) toward the fusion loop, buried...
15.
Alvarado D, Klein D, Lemmon M
Cell
. 2010 Aug;
142(4):568-79.
PMID: 20723758
Transmembrane signaling by the epidermal growth factor receptor (EGFR) involves ligand-induced dimerization and allosteric regulation of the intracellular tyrosine kinase domain. Crystallographic studies have shown how ligand binding induces dimerization...
16.
Alvarado D, Klein D, Lemmon M
Nature
. 2009 Sep;
461(7261):287-91.
PMID: 19718021
The orphan receptor tyrosine kinase ErbB2 (also known as HER2 or Neu) transforms cells when overexpressed, and it is an important therapeutic target in human cancer. Structural studies have suggested...
17.
Klein D, Stayrook S, Shi F, Narayan K, Lemmon M
Nature
. 2008 May;
453(7199):1271-5.
PMID: 18500331
Members of the epidermal growth factor receptor (EGFR) or ErbB/HER family and their activating ligands are essential regulators of diverse developmental processes. Inappropriate activation of these receptors is a key...
18.
Reeves G, Kalifa R, Klein D, Lemmon M, Shvartsman S
Dev Biol
. 2005 Jun;
284(2):523-35.
PMID: 15982648
Argos, a secreted inhibitor of the Drosophila epidermal growth factor receptor, and the only known secreted receptor tyrosine kinase inhibitor, acts by sequestering the EGFR ligand Spitz. We use computational...
19.
Klein D, Nappi V, Reeves G, Shvartsman S, Lemmon M
Nature
. 2004 Aug;
430(7003):1040-4.
PMID: 15329724
The epidermal growth factor receptor (EGFR) has critical functions in development and in many human cancers. During development, the spatial extent of EGFR signalling is regulated by feedback loops comprising...