Darrell N Kotton
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Explore the profile of Darrell N Kotton including associated specialties, affiliations and a list of published articles.
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Articles
156
Citations
6186
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Recent Articles
1.
Burgess C, Ayers L, Minakin K, Alysandratos K, Varelas X, Kotton D
STAR Protoc
. 2025 Mar;
6(1):103667.
PMID: 40048418
Pulmonary alveolar epithelial type I (AT1) cells have a flattened morphology to permit the diffusion of oxygen into the capillaries and historically have been difficult to isolate or maintain in...
2.
Evdokimova M, Feng S, Caobi A, Moreira F, Jones D, Alysandratos K, et al.
Proc Natl Acad Sci U S A
. 2025 Mar;
122(10):e2419620122.
PMID: 40035769
Identifying conserved mechanisms used by viruses to delay host innate responses can reveal potential targets for antiviral therapeutics. Here, we investigated coronavirus nonstructural protein 15 (nsp15), which encodes a highly...
3.
Berical A, Kiyokawa H, Beermann M, Wallman D, Cherfane G, Dunphy V, et al.
Am J Respir Crit Care Med
. 2025 Feb;
PMID: 39999444
No abstract available.
4.
Eiken M, Childs C, Brastrom L, Frum T, Plaster E, Ahmed D, et al.
Stem Cell Reports
. 2024 Dec;
20(1):102376.
PMID: 39672155
Human induced pluripotent stem cell (iPSC)-derived alveolar organoids have emerged as a system to model the alveolar epithelium in homeostasis and disease. However, alveolar organoids are typically grown in Matrigel,...
5.
Kohn A, Herriges M, Basak P, Ma L, Thapa B, Kotton D, et al.
bioRxiv
. 2024 Nov;
PMID: 39605510
Transplantation of airway basal stem cells could achieve a durable cure for genetic diseases of the airway, such as cystic fibrosis and primary ciliary dyskinesia. Recent work demonstrated the potential...
6.
Kinstlinger I, Neu E, Mowry S, Tous C, Kotton D, Wong W
bioRxiv
. 2024 Nov;
PMID: 39574668
Light is a powerful and flexible input into engineered biological systems and is particularly well-suited for spatially controlling genetic circuits. While many light-responsive molecular effectors have been developed, there remains...
7.
Undeutsch H, Posabella A, Alber A, Bawa P, Villacorta-Martin C, Wang F, et al.
Stem Cell Reports
. 2024 Nov;
19(12):1690-1705.
PMID: 39515316
The production of mature functioning thyroid follicular cells (TFCs) from human induced pluripotent stem cells (iPSCs) is critical for potential novel therapeutic approaches to post-surgical and congenital hypothyroidism. To accomplish...
8.
Berical A, Kiyokawa H, Beermann M, Wallman D, Cherfane G, Dunphy V, et al.
Am J Respir Crit Care Med
. 2024 Nov;
PMID: 39514838
No abstract available.
9.
Ma L, Thapa B, Le Suer J, Tilston-Lunel A, Herriges M, Wang F, et al.
Nat Protoc
. 2024 Nov;
20(3):810-842.
PMID: 39501108
Durable and functional regeneration of the airway epithelium in vivo with transplanted stem cells has the potential to reconstitute healthy tissue in diseased airways, such as in cystic fibrosis or...
10.
Tang X, Wei W, Sun Y, Weaver T, Nakayasu E, Clair G, et al.
J Clin Invest
. 2024 Oct;
134(23).
PMID: 39405113
The most common mutation in surfactant protein C gene (SFTPC), SFTPCI73T, causes interstitial lung disease with few therapeutic options. We previously demonstrated that EMC3, an important component of the multiprotein...