Laertis Ikonomou
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Explore the profile of Laertis Ikonomou including associated specialties, affiliations and a list of published articles.
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49
Citations
1259
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Recent Articles
1.
Maryamchik E, Ikonomou L, Roxland B, Grignon F, Levine B, Grilley B
Cytotherapy
. 2025 Mar;
PMID: 40029229
This position paper reviews the Expanded Access pathway for cell and gene therapies, examining its critical role at the nexus of patient need, regulatory frameworks, and scientific advancement. Spearheaded by...
2.
Undeutsch H, Posabella A, Alber A, Bawa P, Villacorta-Martin C, Wang F, et al.
Stem Cell Reports
. 2024 Nov;
19(12):1690-1705.
PMID: 39515316
The production of mature functioning thyroid follicular cells (TFCs) from human induced pluripotent stem cells (iPSCs) is critical for potential novel therapeutic approaches to post-surgical and congenital hypothyroidism. To accomplish...
3.
Ikonomou L, Munsie M, Power C, Sipp D, Turner L, Rasko J
Cell Stem Cell
. 2024 Oct;
31(10):1393-1397.
PMID: 39366360
The rapid proliferation of businesses engaged in direct-to-consumer advertising of unproven stem cell interventions has raised troubling questions about whether government bodies can regulate this health market effectively. Recent developments...
4.
Hynds R, Magin C, Ikonomou L, Aschner Y, Beers M, Burgess J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 May;
327(3):L327-L340.
PMID: 38772903
Repair and regeneration of a diseased lung using stem cells or bioengineered tissues is an exciting therapeutic approach for a variety of lung diseases and critical illnesses. Over the past...
5.
Yampolskaya M, Herriges M, Ikonomou L, Kotton D, Mehta P
Development
. 2023 Sep;
150(21).
PMID: 37756586
Advances in single-cell RNA sequencing provide an unprecedented window into cellular identity. The abundance of data requires new theoretical and computational frameworks to analyze the dynamics of differentiation and integrate...
6.
Ikonomou L, Yampolskaya M, Mehta P
Adv Exp Med Biol
. 2023 Aug;
1413:C3-C4.
PMID: 37561327
No abstract available.
7.
Ikonomou L, Cuende N, Forte M, Grilley B, Levine A, Munsie M, et al.
Cytotherapy
. 2023 Jul;
25(9):920-929.
PMID: 37517865
The field of regenerative medicine, including cellular immunotherapies, is on a remarkable growth trajectory. Dozens of cell-, tissue- and gene-based products have received marketing authorization worldwide while hundreds-to-thousands are either...
8.
Hoffman E, Uriarte J, Uhl F, Eckstrom K, Tanneberger A, Becker C, et al.
Sci Rep
. 2023 Jul;
13(1):12057.
PMID: 37491483
Alveolar type 2 epithelial cells (AT2s) derived from human induced pluripotent stem cells (iAT2s) have rapidly contributed to our understanding of AT2 function and disease. However, while iAT2s are primarily...
9.
Alber A, Marquez H, Ma L, Kwong G, Thapa B, Villacorta-Martin C, et al.
Nat Commun
. 2023 Jun;
14(1):3488.
PMID: 37311756
While the generation of many lineages from pluripotent stem cells has resulted in basic discoveries and clinical trials, the derivation of tissue-specific mesenchyme via directed differentiation has markedly lagged. The...
10.
Ikonomou L, Yampolskaya M, Mehta P
Adv Exp Med Biol
. 2023 May;
1413:49-70.
PMID: 37195526
Transient, tissue-specific, embryonic progenitors are important cell populations in vertebrate development. In the course of respiratory system development, multipotent mesenchymal and epithelial progenitors drive the diversification of fates that results...