Darrell N Kotton
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Explore the profile of Darrell N Kotton including associated specialties, affiliations and a list of published articles.
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156
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6186
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Recent Articles
11.
Gagnon K, Huang J, Hix O, Hui V, Hinds A, Bullitt E, et al.
APL Bioeng
. 2024 Jun;
8(2):026126.
PMID: 38911024
Previous lung-on-chip devices have facilitated significant advances in our understanding of lung biology and pathology. Here, we describe a novel lung-on-a-chip model in which human induced pluripotent stem cell-derived alveolar...
12.
Tang W, Huang J, Pegoraro A, Zhang J, Tang Y, Bi D, et al.
bioRxiv
. 2024 Apr;
PMID: 38659777
Within multicellular living systems, cells coordinate their positions with spatiotemporal accuracy to form various structures, setting the clock to control developmental processes and trigger maturation. These arrangements can be regulated...
13.
Burgess C, Huang J, Bawa P, Alysandratos K, Minakin K, Ayers L, et al.
Cell Stem Cell
. 2024 Apr;
31(5):657-675.e8.
PMID: 38642558
Alveolar epithelial type I cells (AT1s) line the gas exchange barrier of the distal lung and have been historically challenging to isolate or maintain in cell culture. Here, we engineer...
14.
Rodriguez L, Alysandratos K, Katzen J, Murthy A, Roque Barboza W, Tomer Y, et al.
bioRxiv
. 2024 Apr;
PMID: 38585863
Alveolar epithelial type II (AT2) cell dysfunction is implicated in the pathogenesis of familial and sporadic idiopathic pulmonary fibrosis (IPF). We previously described that expression of an AT2 cell exclusive...
15.
Eiken M, Childs C, Brastrom L, Frum T, Plaster E, Shachaf O, et al.
bioRxiv
. 2024 Apr;
PMID: 38562781
Human induced pluripotent stem cell (iPSC) derived alveolar organoids have emerged as a system to model the alveolar epithelium in homeostasis and disease. However, alveolar organoids are typically grown in...
16.
Basil M, Alysandratos K, Kotton D, Morrisey E
Cell Stem Cell
. 2024 Mar;
31(4):439-454.
PMID: 38492572
The respiratory system acts as both the primary site of gas exchange and an important sensor and barrier to the external environment. The increase in incidences of respiratory disease over...
17.
Miao Y, Tan C, Pek N, Yu Z, Iwasawa K, Kechele D, et al.
bioRxiv
. 2024 Feb;
PMID: 38370768
Highlights: BMP signaling fine-tunes the co-differentiation of mesoderm and endoderm.The cellular composition in multilineage organoids resembles that of human fetal organs.Mesenchyme and endothelium co-developed within the organoids adopt organ-specific characteristics.Multilineage...
18.
Hume A, Olejnik J, White M, Huang J, Turcinovic J, Heiden B, et al.
Pathogens
. 2024 Jan;
13(1).
PMID: 38251369
Single-cell RNA sequencing (scRNA-seq) technologies are instrumental to improving our understanding of virus-host interactions in cell culture infection studies and complex biological systems because they allow separating the transcriptional signatures...
19.
Sun Y, Hennessey E, Heins H, Yang P, Villacorta-Martin C, Kwan J, et al.
J Clin Invest
. 2024 Jan;
134(2).
PMID: 38226623
Mutations in ATP-binding cassette A3 (ABCA3), a phospholipid transporter critical for surfactant homeostasis in pulmonary alveolar type II epithelial cells (AEC2s), are the most common genetic causes of childhood interstitial...
20.
Montesi S, Gomez C, Beers M, Brown R, Chattopadhyay I, Flaherty K, et al.
Am J Respir Crit Care Med
. 2023 Dec;
209(4):362-373.
PMID: 38113442
Despite progress in elucidation of disease mechanisms, identification of risk factors, biomarker discovery, and the approval of two medications to slow lung function decline in idiopathic pulmonary fibrosis and one...