Danny Leung
Overview
Explore the profile of Danny Leung including associated specialties, affiliations and a list of published articles.
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23
Citations
5740
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Recent Articles
1.
Leung D, Liu K
Mol Cancer Res
. 2025 Feb;
PMID: 39945628
Approximately 97% of the human genome comprises non-coding sequences, with nearly half originating from transposable elements. Among these, retrotransposons represent a critical subclass that replicates via a "copy-and-paste" mechanism and...
2.
Tam P, Cheung M, Chan L, Leung D
Nat Commun
. 2024 Jan;
15(1):15.
PMID: 38167730
SETDB1 is an essential histone methyltransferase that deposits histone H3 lysine 9 trimethylation (H3K9me3) to transcriptionally repress genes and repetitive elements. The function of differential H3K9me3 enrichment between cell-types remains...
3.
Tam P, Leung D
Int J Mol Sci
. 2023 Nov;
24(22).
PMID: 38003607
Retrotransposons are invasive genetic elements that constitute substantial portions of mammalian genomes. They have the potential to influence nearby gene expression through their -regulatory sequences, reverse transcription machinery, and the...
4.
Takakura M, Lam Y, Nakagawa R, Ng M, Hu X, Bhargava P, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(36):e2304851120.
PMID: 37639608
Memory formation and forgetting unnecessary memory must be balanced for adaptive animal behavior. While cyclic AMP (cAMP) signaling via dopamine neurons induces memory formation, here we report that cyclic guanine...
5.
Gao L, Mathur V, Tam S, Zhou X, Cheung M, Chan L, et al.
Nat Cell Biol
. 2023 Jul;
25(7):1047-1060.
PMID: 37400500
During pregnancy the maternal-fetal interface plays vital roles in fetal development. Its disruption is frequently found in pregnancy complications. Recent studies show increased incidences of adverse pregnancy outcomes in patients...
6.
Zhou X, Sam T, Lee A, Leung D
Nat Commun
. 2021 Nov;
12(1):6462.
PMID: 34753915
Polymorphic integrations of endogenous retroviruses (ERVs) have been previously detected in mouse and human genomes. While most are inert, a subset can influence the activity of the host genes. However,...
7.
Song X, Aw J, Ma F, Cheung M, Leung D, Herrup K
J Neurosci
. 2021 Oct;
41(45):9286-9307.
PMID: 34593604
Adult-onset neurodegenerative diseases are often accompanied by evidence of a chronic inflammation that includes activation of microglial cells and altered levels of brain cytokines. Aspects of this response are likely...
8.
Klein K, Zhao P, Lyu X, Sasaki T, Bartlett D, Singh A, et al.
Science
. 2021 Apr;
372(6540):371-378.
PMID: 33888635
The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin modifications and three-dimensional genome architecture; however, causal links have not been established, largely because of an inability...
9.
Lee C, Cheung M, Li J, Zhao Y, Lam W, Ho V, et al.
Nat Commun
. 2021 Jan;
12(1):33.
PMID: 33397927
The Origin Recognition Complex (ORC) is an evolutionarily conserved six-subunit protein complex that binds specific sites at many locations to coordinately replicate the entire eukaryote genome. Though highly conserved in...
10.
Chaglasian M, Fingeret M, Davey P, Huang W, Leung D, Ng E, et al.
Clin Ophthalmol
. 2018 May;
12:849-857.
PMID: 29765199
Importance: The paper presents the range for measurements taken with a new spectral domain optical coherence tomography (OCT) device to establish a reference database for discrimination purposes. Objective: To report...