Danny Leung
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Explore the profile of Danny Leung including associated specialties, affiliations and a list of published articles.
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23
Citations
5740
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Recent Articles
11.
Zhang W, Xia W, Wang Q, Towers A, Chen J, Gao R, et al.
Mol Cell
. 2016 Dec;
64(6):1062-1073.
PMID: 27916660
The methylcytosine oxidase TET proteins play important roles in DNA demethylation and development. However, it remains elusive how exactly they target substrates and execute oxidation. Interestingly, we found that, in...
12.
Schultz M, He Y, Whitaker J, Hariharan M, Mukamel E, Leung D, et al.
Nature
. 2015 Nov;
530(7589):242.
PMID: 26605523
No abstract available.
13.
Kelsey A, Yang C, Leung D, Minks J, Dixon-McDougall T, Baldry S, et al.
Genome Biol
. 2015 Oct;
16:208.
PMID: 26429547
Background: X-chromosome inactivation is a striking example of epigenetic silencing in which expression of the long non-coding RNA XIST initiates the heterochromatinization and silencing of one of the pair of...
14.
Schultz M, He Y, Whitaker J, Hariharan M, Mukamel E, Leung D, et al.
Nature
. 2015 Jun;
523(7559):212-6.
PMID: 26030523
Understanding the diversity of human tissues is fundamental to disease and requires linking genetic information, which is identical in most of an individual's cells, with epigenetic mechanisms that could have...
15.
Leung D, Jung I, Rajagopal N, Schmitt A, Selvaraj S, Lee A, et al.
Nature
. 2015 Feb;
518(7539):350-354.
PMID: 25693566
Allelic differences between the two homologous chromosomes can affect the propensity of inheritance in humans; however, the extent of such differences in the human genome has yet to be fully...
16.
Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, et al.
Nature
. 2015 Feb;
518(7539):317-30.
PMID: 25693563
The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need,...
17.
Gorkin D, Leung D, Ren B
Cell Stem Cell
. 2014 Jun;
14(6):762-75.
PMID: 24905166
It can be convenient to think of the genome as simply a string of nucleotides, the linear order of which encodes an organism's genetic blueprint. However, the genome does not...
18.
Leung D, Du T, Wagner U, Xie W, Lee A, Goyal P, et al.
Proc Natl Acad Sci U S A
. 2014 Apr;
111(18):6690-5.
PMID: 24757056
During mammalian development, DNA methylation patterns need to be reset in primordial germ cells (PGCs) and preimplantation embryos. However, many LTR retrotransposons and imprinted genes are impervious to such global...
19.
Xie W, Schultz M, Lister R, Hou Z, Rajagopal N, Ray P, et al.
Cell
. 2013 May;
153(5):1134-48.
PMID: 23664764
Epigenetic mechanisms have been proposed to play crucial roles in mammalian development, but their precise functions are only partially understood. To investigate epigenetic regulation of embryonic development, we differentiated human...
20.
Baradaran-Heravi A, Cho K, Tolhuis B, Sanyal M, Morozova O, Morimoto M, et al.
Hum Mol Genet
. 2012 Mar;
21(11):2572-87.
PMID: 22378147
Biallelic mutations of the DNA annealing helicase SMARCAL1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1) cause Schimke immuno-osseous dysplasia (SIOD, MIM 242900), an incompletely penetrant autosomal recessive disorder....