Nisha Rajagopal
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Explore the profile of Nisha Rajagopal including associated specialties, affiliations and a list of published articles.
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16
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6614
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Recent Articles
1.
Jones T, Feng J, Luyties O, Cozzolino K, Sanford L, Rimel J, et al.
Sci Adv
. 2025 Feb;
11(9):eadr9660.
PMID: 40020069
How cyclin-dependent kinase 7 (CDK7) coordinately regulates the cell cycle and RNA polymerase II transcription remains unclear. Here, high-resolution cryo-electron microscopy revealed how two clinically relevant inhibitors block CDK7 function....
2.
Stein E, de Botton S, Cluzeau T, Pigneux A, Liesveld J, Cook R, et al.
Leuk Lymphoma
. 2023 Aug;
64(12):1992-2001.
PMID: 37571998
Tamibarotene-based therapy is a novel targeted approach for the treatment of relapsed/refractory (R/R) acute myeloid leukemia (AML) with retinoic acid receptor alpha () gene overexpression. Approximately, 50% of higher-risk myelodysplastic...
3.
Secka J, Pal A, Acquah F, Mooers B, Karki A, Mahjoub D, et al.
RSC Adv
. 2022 Jul;
12(30):19431-19444.
PMID: 35865562
This paper describes the synthesis of enamino carbonyl compounds by the copper(i)-catalyzed coupling of acceptor-substituted diazo compounds and tertiary thioamides. We plan to use this method to synthesize indolizidine (-)-237D...
4.
Neyaz L, Rajagopal N, Wells H, Fakhr M
Front Microbiol
. 2020 Mar;
11:223.
PMID: 32140145
is considered one of the most important foodborne bacterial pathogens causing food poisoning and related illnesses. strains harbor plasmids encoding genes for virulence and antimicrobial resistance, but few studies have...
5.
Hu S, Marineau J, Rajagopal N, Hamman K, Choi Y, Schmidt D, et al.
Cancer Res
. 2019 May;
79(13):3479-3491.
PMID: 31064851
Recent studies suggest that targeting transcriptional machinery can lead to potent and selective anticancer effects in cancers dependent on high and constant expression of certain transcription factors for growth and...
6.
Hashimoto T, Sherwood R, Kang D, Rajagopal N, Barkal A, Zeng H, et al.
Genome Res
. 2016 Jul;
26(10):1430-1440.
PMID: 27456004
Enhancers and promoters commonly occur in accessible chromatin characterized by depleted nucleosome contact; however, it is unclear how chromatin accessibility is governed. We show that log-additive cis-acting DNA sequence features...
7.
Rajagopal N, Srinivasan S, Kooshesh K, Guo Y, Edwards M, Banerjee B, et al.
Nat Biotechnol
. 2016 Jan;
34(2):167-74.
PMID: 26807528
Quantifying the effects of cis-regulatory DNA on gene expression is a major challenge. Here, we present the multiplexed editing regulatory assay (MERA), a high-throughput CRISPR-Cas9-based approach that analyzes the functional...
8.
Schultz M, He Y, Whitaker J, Hariharan M, Mukamel E, Leung D, et al.
Nature
. 2015 Nov;
530(7589):242.
PMID: 26605523
No abstract available.
9.
Schultz M, He Y, Whitaker J, Hariharan M, Mukamel E, Leung D, et al.
Nature
. 2015 Jun;
523(7559):212-6.
PMID: 26030523
Understanding the diversity of human tissues is fundamental to disease and requires linking genetic information, which is identical in most of an individual's cells, with epigenetic mechanisms that could have...
10.
Leung D, Jung I, Rajagopal N, Schmitt A, Selvaraj S, Lee A, et al.
Nature
. 2015 Feb;
518(7539):350-354.
PMID: 25693566
Allelic differences between the two homologous chromosomes can affect the propensity of inheritance in humans; however, the extent of such differences in the human genome has yet to be fully...