Daniel R Caffrey
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Explore the profile of Daniel R Caffrey including associated specialties, affiliations and a list of published articles.
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34
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4148
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Recent Articles
1.
Chen Y, Lei X, Jiang Z, Humphries F, Parsi K, Mustone N, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(47):e2308355120.
PMID: 37963251
A detailed understanding of the innate immune mechanisms involved in restricting SARS-CoV-2 infection and how the virus disrupts these processes could reveal new strategies to boost antiviral mechanisms and develop...
2.
Crabtree J, Caffrey D, de Souza Silva L, Kurt-Jones E, Dobbs K, Dent A, et al.
J Clin Invest
. 2022 Jun;
132(11).
PMID: 35642634
Plasmodium falciparum (P. falciparum) induces trained innate immune responses in vitro, where initial stimulation of adherent PBMCs with P. falciparum-infected RBCs (iRBCs) results in hyperresponsiveness to subsequent ligation of TLR2....
3.
Sciabola S, Xi H, Cruz D, Cao Q, Lawrence C, Zhang T, et al.
PLoS One
. 2021 Jan;
16(1):e0238753.
PMID: 33481821
PFRED a software application for the design, analysis, and visualization of antisense oligonucleotides and siRNA is described. The software provides an intuitive user-interface for scientists to design a library of...
4.
Tzeng T, Hasegawa Y, Iguchi R, Cheung A, Caffrey D, Thatcher E, et al.
Proc Natl Acad Sci U S A
. 2018 Aug;
115(36):9002-9007.
PMID: 30127003
Alzheimer's disease (AD) is characterized by the progressive destruction and dysfunction of central neurons. AD patients commonly have unprovoked seizures compared with age-matched controls. Amyloid peptide-related inflammation is thought to...
5.
Canale A, Venev S, Whitfield T, Caffrey D, Marasco W, Schiffer C, et al.
J Mol Biol
. 2018 Feb;
430(8):1098-1115.
PMID: 29466705
The fitness effects of synonymous mutations can provide insights into biological and evolutionary mechanisms. We analyzed the experimental fitness effects of all single-nucleotide mutations, including synonymous substitutions, at the beginning...
6.
SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans
Paik D, Monahan A, Caffrey D, Elling R, Goldman W, Silverman N
J Immunol
. 2017 May;
199(1):263-270.
PMID: 28539433
Tracheal cytotoxin (TCT), a monomer of DAP-type peptidoglycan from , causes cytopathology in the respiratory epithelia of mammals and robustly triggers the Imd pathway. PGRP-LE, a cytosolic innate immune sensor...
7.
Kalantari P, Harandi O, Agarwal S, Rus F, Kurt-Jones E, Fitzgerald K, et al.
J Biol Chem
. 2017 Feb;
292(14):5634-5644.
PMID: 28209713
Bacterial sepsis involves a complex interaction between the host immune response and bacterial LPS. LPS binds Toll-like receptor (TLR) 4, which leads to the release of proinflammatory cytokines that are...
8.
Atianand M, Caffrey D, Fitzgerald K
Annu Rev Immunol
. 2017 Jan;
35:177-198.
PMID: 28125358
The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that interact with RNA, DNA, or...
9.
Atianand M, Hu W, Satpathy A, Shen Y, Ricci E, Alvarez-Dominguez J, et al.
Cell
. 2016 Jun;
165(7):1672-1685.
PMID: 27315481
Long intergenic noncoding RNAs (lincRNAs) are important regulators of gene expression. Although lincRNAs are expressed in immune cells, their functions in immunity are largely unexplored. Here, we identify an immunoregulatory...
10.
Gulia-Nuss M, Nuss A, Meyer J, Sonenshine D, Roe R, Waterhouse R, et al.
Nat Commun
. 2016 Feb;
7:10507.
PMID: 26856261
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause...