Konstantin B Zeldovich
Overview
Explore the profile of Konstantin B Zeldovich including associated specialties, affiliations and a list of published articles.
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29
Citations
1075
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Recent Articles
1.
Ustyugova I, Pougatcheva S, Farrell T, Strugnell T, Ganesh V, Zeldovich K, et al.
Vaccine
. 2023 Feb;
41(12):2022-2034.
PMID: 36803901
Seasonal influenza remains a serious public health concern as the viral infection spreads easily from person to person and due to antigenic drift of neutralizing epitopes. Vaccination is the best...
2.
Cote-Hammarlof P, Fragata I, Flynn J, Mavor D, Zeldovich K, Bank C, et al.
Mol Biol Evol
. 2020 Sep;
38(2):368-379.
PMID: 32871012
The distribution of fitness effects (DFEs) of new mutations across different environments quantifies the potential for adaptation in a given environment and its cost in others. So far, results regarding...
3.
Chan Y, Zeldovich K, Matthews C
Protein Sci
. 2020 Jul;
29(9):1911-1923.
PMID: 32643222
Protein evolution proceeds by a complex response of organismal fitness to mutations that can simultaneously affect protein stability, structure, and enzymatic activity. To probe the relationship between genotype and phenotype,...
4.
Whitfield T, Ragland D, Zeldovich K, Schiffer C
J Chem Theory Comput
. 2019 Dec;
16(2):1284-1299.
PMID: 31877249
Over the past several decades, atomistic simulations of biomolecules, whether carried out using molecular dynamics or Monte Carlo techniques, have provided detailed insights into their function. Comparing the results of...
5.
Boucher J, Whitfield T, Dauphin A, Nachum G, Hollins C, Zeldovich K, et al.
Mol Biol Evol
. 2019 Feb;
36(4):798-810.
PMID: 30721995
The evolution of HIV-1 protein sequences should be governed by a combination of factors including nucleotide mutational probabilities, the genetic code, and fitness. The impact of these factors on protein...
6.
Prachanronarong K, Canale A, Liu P, Somasundaran M, Hou S, Poh Y, et al.
J Virol
. 2018 Nov;
93(2).
PMID: 30381484
Influenza A virus (IAV), a major cause of human morbidity and mortality, continuously evolves in response to selective pressures. Stem-directed, broadly neutralizing antibodies (sBnAbs) targeting the influenza virus hemagglutinin (HA)...
7.
Canale A, Venev S, Whitfield T, Caffrey D, Marasco W, Schiffer C, et al.
J Mol Biol
. 2018 Feb;
430(8):1098-1115.
PMID: 29466705
The fitness effects of synonymous mutations can provide insights into biological and evolutionary mechanisms. We analyzed the experimental fitness effects of all single-nucleotide mutations, including synonymous substitutions, at the beginning...
8.
Venev S, Zeldovich K
Mol Biol Evol
. 2017 Nov;
35(1):211-224.
PMID: 29106597
Prokaryotes evolved to thrive in an extremely diverse set of habitats, and their proteomes bear signatures of environmental conditions. Although correlations between amino acid usage and environmental temperature are well-documented,...
9.
Ragland D, Whitfield T, Lee S, Swanstrom R, Zeldovich K, Kurt-Yilmaz N, et al.
J Chem Theory Comput
. 2017 Sep;
13(11):5671-5682.
PMID: 28915040
HIV-1 protease is responsible for the cleavage of 12 nonhomologous sites within the Gag and Gag-Pro-Pol polyproteins in the viral genome. Under the selective pressure of protease inhibition, the virus...
10.
Chan Y, Venev S, Zeldovich K, Matthews C
Nat Commun
. 2017 Mar;
8:14614.
PMID: 28262665
Sequence divergence of orthologous proteins enables adaptation to environmental stresses and promotes evolution of novel functions. Limits on evolution imposed by constraints on sequence and structure were explored using a...