Alpha 2.0
Login Register
» Authors » Daniel Aiello

Daniel Aiello

Explore the profile of Daniel Aiello including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 841
Followers 0
Related Specialties
Biochemistry
Pharmacology
Chemistry
Top 10 Co-Authors
Donald T Moir
Terry L Bowlin
Norton P Peet
John D Williams
Daniel R Caffrey
Bing Li
Marjorie H Barnes
Ming Di
Tommy F Tashjian
Katherine A Fitzgerald
Published In
Antimicrob Agents Chemother
Bioorg Med Chem
J Med Chem
J Virol
Bioorg Med Chem Lett
Affiliations
Soon will be listed here.
Recent Articles
1.
DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics
Opperman T, Kwasny S, Li J, Lewis M, Aiello D, Williams J, et al.
Antimicrob Agents Chemother . 2016 Sep; 60(12):7067-7076. PMID: 27620482
We previously reported the synthesis and biological activity of a series of cationic bis-indoles with potent, broad-spectrum antibacterial properties. Here, we describe mechanism of action studies to test the hypothesis...
2.
Cutting Edge: A Natural Antisense Transcript, AS-IL1α, Controls Inducible Transcription of the Proinflammatory Cytokine IL-1α
Chan J, Atianand M, Jiang Z, Carpenter S, Aiello D, Elling R, et al.
J Immunol . 2015 Jul; 195(4):1359-63. PMID: 26179904
Natural antisense transcripts (NATs) are a class of long noncoding RNAs (lncRNAs) that are complementary to other protein-coding genes. Although thousands of NATs are encoded by mammalian genomes, their functions...
3.
Synthesis and structure-activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS)
Williams J, Torhan M, Neelagiri V, Brown C, Bowlin N, Di M, et al.
Bioorg Med Chem . 2015 Feb; 23(5):1027-43. PMID: 25638499
The increasing prevalence of drug-resistant bacterial infections is driving the discovery and development not only of new antibiotics, but also of inhibitors of virulence factors that are crucial for in...
4.
Mutations in the Pseudomonas aeruginosa needle protein gene pscF confer resistance to phenoxyacetamide inhibitors of the type III secretion system
Bowlin N, Williams J, Knoten C, Torhan M, Tashjian T, Li B, et al.
Antimicrob Agents Chemother . 2014 Jan; 58(4):2211-20. PMID: 24468789
The type III secretion system (T3SS) is a clinically important virulence mechanism in Pseudomonas aeruginosa that secretes and translocates effector toxins into host cells, impeding the host's rapid innate immune...
5.
Distinct cellular origins for serotonin-expressing and enterochromaffin-like cells in the gastric corpus
Li H, Johnston B, Aiello D, Caffrey D, Giel-Moloney M, Rindi G, et al.
Gastroenterology . 2013 Dec; 146(3):754-764.e3. PMID: 24316261
Background & Aims: The alimentary tract contains a diffuse endocrine system comprising enteroendocrine cells that secrete peptides or biogenic amines to regulate digestion, insulin secretion, food intake, and energy homeostasis....
6.
Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro
Renzette N, Caffrey D, Zeldovich K, Liu P, Gallagher G, Aiello D, et al.
J Virol . 2013 Oct; 88(1):272-81. PMID: 24155392
Influenza A virus (IAV) is a major cause of morbidity and mortality throughout the world. Current antiviral therapies include oseltamivir, a neuraminidase inhibitor that prevents the release of nascent viral...
7.
A long noncoding RNA mediates both activation and repression of immune response genes
Carpenter S, Aiello D, Atianand M, Ricci E, Gandhi P, Hall L, et al.
Science . 2013 Aug; 341(6147):789-92. PMID: 23907535
An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin-modifying factors....
8.
Optimization of a novel potent and selective bacterial DNA helicase inhibitor scaffold from a high throughput screening hit
Li B, Pai R, Aiello D, Di M, Barnes M, Peet N, et al.
Bioorg Med Chem Lett . 2013 May; 23(12):3481-6. PMID: 23664213
Benzobisthiazole derivatives were identified as novel helicase inhibitors through high throughput screening against purified Staphylococcus aureus (Sa) and Bacillus anthracis (Ba) replicative helicases. Chemical optimization has produced compound 59 with...
9.
Coumarin-based inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicase: chemical optimization, biological evaluation, and antibacterial activities
Li B, Pai R, Di M, Aiello D, Barnes M, Butler M, et al.
J Med Chem . 2012 Dec; 55(24):10896-908. PMID: 23231076
The increasing prevalence of drug-resistant bacterial infections demands the development of new antibacterials that are not subject to existing mechanisms of resistance. Previously, we described coumarin-based inhibitors of an underexploited...
10.
Evolution of specific protein-protein interaction sites following gene duplication
Aiello D, Caffrey D
J Mol Biol . 2012 Jul; 423(2):257-72. PMID: 22789570
Gene duplication is a common evolutionary process that leads to the expansion and functional diversification of protein subfamilies. The evolutionary events that cause paralogous proteins to bind different protein ligands...