Daniel L Parton
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Explore the profile of Daniel L Parton including associated specialties, affiliations and a list of published articles.
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11
Citations
258
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Recent Articles
1.
Albanese S, Parton D, Isik M, Rodriguez-Laureano L, Hanson S, Behr J, et al.
Biochemistry
. 2018 Jul;
57(31):4675-4689.
PMID: 30004690
Kinases play a critical role in cellular signaling and are dysregulated in a number of diseases, such as cancer, diabetes, and neurodegeneration. Therapeutics targeting kinases currently account for roughly 50%...
2.
Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin
Xu J, Pham C, Albanese S, Dong Y, Oyama T, Lee C, et al.
J Clin Invest
. 2016 Aug;
126(9):3526-40.
PMID: 27482884
Genomic studies have linked mTORC1 pathway-activating mutations with exceptional response to treatment with allosteric inhibitors of mTORC1 called rapalogs. Rapalogs are approved for selected cancer types, including kidney and breast...
3.
Parton D, Grinaway P, Hanson S, Beauchamp K, Chodera J
PLoS Comput Biol
. 2016 Jun;
12(6):e1004728.
PMID: 27337644
The rapidly expanding body of available genomic and protein structural data provides a rich resource for understanding protein dynamics with biomolecular simulation. While computational infrastructure has grown rapidly, simulations on...
4.
Reddy T, Shorthouse D, Parton D, Jefferys E, Fowler P, Chavent M, et al.
Structure
. 2015 Feb;
23(3):584-597.
PMID: 25703376
The influenza virus is surrounded by an envelope composed of a lipid bilayer and integral membrane proteins. Understanding the structural dynamics of the membrane envelope provides biophysical insights into aspects...
5.
Baker J, Courtemanche N, Parton D, McCullagh M, Pollard T, Voth G
Structure
. 2014 Dec;
23(1):68-79.
PMID: 25482541
Formins catalyze nucleation and growth of actin filaments. Here, we study the structure and interactions of actin with the FH2 domain of budding yeast formin Bni1p. We built an all-atom...
6.
Parton D, Tek A, Baaden M, Sansom M
PLoS Comput Biol
. 2013 Apr;
9(4):e1003034.
PMID: 23592976
The association of hemagglutinin (HA) with lipid rafts in the plasma membrane is an important feature of the assembly process of influenza virus A. Lipid rafts are thought to be...
7.
Crowet J, Parton D, Hall B, Steinhauer S, Brasseur R, Lins L, et al.
J Phys Chem B
. 2012 Oct;
116(46):13713-21.
PMID: 23094791
Fusion peptides of type I fusion glycoproteins are structural elements of several enveloped viruses which enable the fusion between host and virus membranes. It is generally suggested that these peptides...
8.
Parton D, Akhmatskaya E, Sansom M
J Phys Chem B
. 2012 Mar;
116(29):8485-93.
PMID: 22380536
The antimicrobial peptide maculatin 1.1 (M1.1) is an amphipathic α-helix that permeabilizes lipid bilayers. In coarse-grained molecular dynamics (CG MD) simulations, M1.1 has previously been shown to form membrane-spanning aggregates...
9.
Parton D, Klingelhoefer J, Sansom M
Biophys J
. 2011 Aug;
101(3):691-9.
PMID: 21806937
Aggregation of transmembrane proteins is important for many biological processes, such as protein sorting and cell signaling, and also for in vitro processes such as two-dimensional crystallization. We have used...
10.
Procopiou P, Browning C, Buckley J, Clark K, Fechner L, Gore P, et al.
J Med Chem
. 2011 Mar;
54(7):2183-95.
PMID: 21381763
A series of potent phthalazinone-based human H(1) and H(3) bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis, were identified. Blockade of H(3) receptors...