Sonya M Hanson
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Explore the profile of Sonya M Hanson including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
337
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Recent Articles
1.
Gumbart J, Hanson S
J Phys Chem B
. 2025 Mar;
129(10):2657-2658.
PMID: 40078023
No abstract available.
2.
Ojha A, Blackwell R, Cruz-Chu E, Dsouza R, Astore M, Schwander P, et al.
Acta Crystallogr D Struct Biol
. 2025 Feb;
81(Pt 3):89-104.
PMID: 40019002
Resolving continuous conformational heterogeneity in single-particle cryo-electron microscopy (cryo-EM) is a field in which new methods are now emerging regularly. Methods range from traditional statistical techniques to state-of-the-art neural network...
3.
Bullerjahn J, Hanson S
Temperature (Austin)
. 2024 Apr;
11(1):60-71.
PMID: 38577298
Transient receptor potential (TRP) ion channels are among the most well-studied classes of temperature-sensing molecules. Yet, the molecular mechanism and thermodynamic basis for the temperature sensitivity of TRP channels remains...
4.
Ishigami Y, Wong M, Marti-Gomez C, Ayaz A, Kooshkbaghi M, Hanson S, et al.
Nat Commun
. 2024 Feb;
15(1):1880.
PMID: 38424098
Drugs that target pre-mRNA splicing hold great therapeutic potential, but the quantitative understanding of how these drugs work is limited. Here we introduce mechanistically interpretable quantitative models for the sequence-specific...
5.
Astore M, Pradhan A, Thiede E, Hanson S
Curr Opin Struct Biol
. 2024 Jan;
84:102768.
PMID: 38215528
Allostery is the mechanism by which information and control are propagated in biomolecules. It regulates ligand binding, chemical reactions, and conformational changes. An increasing level of experimental resolution and control...
6.
Hanson S, Scholuke J, Liewald J, Sharma R, Ruse C, Engel M, et al.
Curr Biol
. 2023 Aug;
33(16):3423-3435.e5.
PMID: 37527662
Sensation of light is essential for all organisms. The eye-less nematode Caenorhabditis elegans detects UV and blue light to evoke escape behavior. The photosensor LITE-1 absorbs UV photons with an...
7.
Tang W, Zhong E, Hanson S, Thiede E, Cossio P
Curr Opin Struct Biol
. 2023 Jun;
81:102626.
PMID: 37311334
Single-particle cryo-electron microscopy (cryo-EM) is a technique that takes projection images of biomolecules frozen at cryogenic temperatures. A major advantage of this technique is its ability to image single biomolecules...
8.
Tang W, Silva-Sanchez D, Giraldo-Barreto J, Carpenter B, Hanson S, Barnett A, et al.
J Phys Chem B
. 2023 Jun;
127(24):5410-5421.
PMID: 37293763
Cryo-electron microscopy (cryo-EM) has recently become a leading method for obtaining high-resolution structures of biological macromolecules. However, cryo-EM is limited to biomolecular samples with low conformational heterogeneity, where most conformations...
9.
Hanson S, Georghiou G, Thakur M, Miller W, Rest J, Chodera J, et al.
Cell Chem Biol
. 2019 Jan;
26(3):390-399.e5.
PMID: 30612951
ATP-competitive kinase inhibitors often bind several kinases due to the high conservation of the ATP binding pocket. Through clustering analysis of a large kinome profiling dataset, we found a cluster...
10.
Albanese S, Parton D, Isik M, Rodriguez-Laureano L, Hanson S, Behr J, et al.
Biochemistry
. 2018 Jul;
57(31):4675-4689.
PMID: 30004690
Kinases play a critical role in cellular signaling and are dysregulated in a number of diseases, such as cancer, diabetes, and neurodegeneration. Therapeutics targeting kinases currently account for roughly 50%...