Andrew J Peat
Overview
Explore the profile of Andrew J Peat including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
415
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0
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Recent Articles
1.
Pero J, Mueller E, Adams A, Adolph R, Bagchi P, Balce D, et al.
J Med Chem
. 2024 Aug;
67(16):14586-14608.
PMID: 39136957
In the aftermath of the COVID-19 pandemic, opportunities to modulate biological pathways common to the lifecycles of viruses need to be carefully considered. -linked glycosylation in humans is mediated exclusively...
2.
Madan A, Chen S, Yates P, Washburn M, Roberts G, Peat A, et al.
Open Forum Infect Dis
. 2019 May;
6(4):ofz163.
PMID: 31041358
Background: Excessive neutrophil migration has been correlated with influenza symptom severity. Danirixin (GSK1325756), a selective and reversible antagonist of C-X-C chemokine receptor 2, decreases neutrophil activation and transmigration to areas...
3.
Roberts G, Chen S, Yates P, Madan A, Walker J, Washburn M, et al.
Open Forum Infect Dis
. 2019 Apr;
6(4):ofz072.
PMID: 31024969
Background: Danirixin (DNX), a selective and reversible CXC chemokine receptor 2 antagonist, inhibits neutrophil transmigration and activation. This study assessed the safety, tolerability, and clinical effect of DNX with and...
4.
Chong P, Shotwell J, Miller J, Price D, Maynard A, Voitenleitner C, et al.
J Med Chem
. 2019 Feb;
62(7):3254-3267.
PMID: 30763090
We previously described the discovery of GSK5852 (1), a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV), in which an N-benzyl boronic acid was essential for potent antiviral activity....
5.
Phelan J, Lang S, Sim J, Berritt S, Peat A, Billings K, et al.
J Am Chem Soc
. 2019 Feb;
141(8):3723-3732.
PMID: 30753065
DNA-encoded library (DEL) technology is a powerful tool commonly used by the pharmaceutical industry for the identification of compounds with affinity to biomolecular targets. Success in this endeavor lies in...
6.
Tran V, Poole D, Jeffery J, Sheahan T, Creech D, Yevtodiyenko A, et al.
Viruses
. 2015 Oct;
7(10):5319-27.
PMID: 26473913
Reporter viruses are useful probes for studying multiple stages of the viral life cycle. Here we describe an expanded toolbox of fluorescent and bioluminescent influenza A reporter viruses. The enhanced...
7.
Pouliot J, Thomson M, Xie M, Horton J, Johnson J, Krull D, et al.
Antimicrob Agents Chemother
. 2015 Aug;
59(10):6539-50.
PMID: 26259798
The hepatitis C virus (HCV) NS4B protein is an antiviral therapeutic target for which small-molecule inhibitors have not been shown to exhibit in vivo efficacy. We describe here the in...
8.
Shotwell J, Baskaran S, Chong P, Creech K, Crosby R, Dickson H, et al.
ACS Med Chem Lett
. 2014 Jun;
3(7):565-9.
PMID: 24900511
A series of imidazo[1,2-a]pyridines which directly bind to HCV Non-Structural Protein 4B (NS4B) is described. This series demonstrates potent in vitro inhibition of HCV replication (EC50 < 10 nM), direct...
9.
Tai V, Garrido D, Price D, Maynard A, Pouliot J, Xiong Z, et al.
Bioorg Med Chem Lett
. 2014 Apr;
24(10):2288-94.
PMID: 24731273
Two novel series of spirocyclic piperidine analogs appended to a pyrazolo[1,5-a]pyridine core were designed, synthesized and evaluated for their anti-HCV activity. A series of piperidine ketals afforded dispiro 6p which...
10.
Maynard A, Crosby R, Ellis B, Hamatake R, Hong Z, Johns B, et al.
J Med Chem
. 2013 May;
57(5):1902-13.
PMID: 23672667
A boronic acid moiety was found to be a critical pharmacophore for enhanced in vitro potency against wild-type hepatitis C replicons and known clinical polymorphic and resistant HCV mutant replicons....