Daniel E Goldberg
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Explore the profile of Daniel E Goldberg including associated specialties, affiliations and a list of published articles.
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126
Citations
3614
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Recent Articles
1.
Godinez-Macias K, Chen D, Wallis J, Siegel M, Adam A, Bopp S, et al.
NPJ Drug Discov
. 2025 Mar;
2(1):3.
PMID: 40066064
Identification of novel drug targets is a key component of modern drug discovery. While antimalarial targets are often identified through the mechanism of action studies on phenotypically derived inhibitors, this...
2.
Zhang Z, Lyu M, Han X, Bandara S, Cui M, Istvan E, et al.
Sci Adv
. 2024 Dec;
10(51):eadq6651.
PMID: 39693420
Malaria, a devastating parasitic infection, is the leading cause of death in many developing countries. Unfortunately, the most deadliest causative agent of malaria, , has developed resistance to nearly all...
3.
Blackwell A, Jami-Alahmadi Y, Nasamu A, Kudo S, Senoo A, Slam C, et al.
Elife
. 2024 Dec;
13.
PMID: 39660822
Malaria parasites have evolved unusual metabolic adaptations that specialize them for growth within heme-rich human erythrocytes. During blood-stage infection, parasites internalize and digest abundant host hemoglobin within the digestive vacuole....
4.
Godinez-Macias K, Chen D, Wallis J, Siegel M, Adam A, Bopp S, et al.
Res Sq
. 2024 Dec;
PMID: 39649165
The identification of novel drug targets for the purpose of designing small molecule inhibitors is key component to modern drug discovery. In malaria parasites, discoveries of antimalarial targets have primarily...
5.
Luth M, Godinez-Macias K, Chen D, Okombo J, Thathy V, Cheng X, et al.
Science
. 2024 Nov;
386(6725):eadk9893.
PMID: 39607932
Surveillance of drug resistance and the discovery of novel targets-key objectives in the fight against malaria-rely on identifying resistance-conferring mutations in parasites. Current approaches, while successful, require laborious experimentation or...
6.
Blackwell A, Jami-Alahmadi Y, Nasamu A, Kudo S, Senoo A, Slam C, et al.
bioRxiv
. 2024 Jun;
PMID: 38853871
Malaria parasites have evolved unusual metabolic adaptations that specialize them for growth within heme-rich human erythrocytes. During blood-stage infection, parasites internalize and digest abundant host hemoglobin within the digestive vacuole....
7.
Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje C, et al.
Nat Commun
. 2024 Jan;
15(1):937.
PMID: 38297033
Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based...
8.
Hasan M, Polino A, Mukherjee S, Vaupel B, Goldberg D
mBio
. 2023 Aug;
14(5):e0121523.
PMID: 37646514
Malaria parasites export hundreds of proteins to the cytoplasm of the host red blood cells for their survival. A five amino acid sequence, called the PEXEL motif, is conserved among...
9.
Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje C, et al.
Res Sq
. 2023 Aug;
PMID: 37546892
Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based...
10.
Nguyen S, Du D, Wychrij D, Cain M, Wu Q, Klein R, et al.
Proc Natl Acad Sci U S A
. 2023 Jun;
120(26):e2306318120.
PMID: 37307435
Histidine-rich protein II (HRPII) is secreted by during the blood stage of malaria infection. High plasma levels of HRPII are associated with cerebral malaria, a severe and highly fatal complication...