Josh R Beck
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Explore the profile of Josh R Beck including associated specialties, affiliations and a list of published articles.
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37
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1362
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Recent Articles
1.
Blauwkamp J, Ambekar S, Hussain T, Mair G, Beck J, Absalon S
mSphere
. 2024 Nov;
9(12):e0075024.
PMID: 39526784
Importance: Malaria, caused by species, remains a critical global health challenge, with an estimated 249 million cases and over 600,000 deaths in 2022, primarily affecting children under five. Understanding the...
2.
Blauwkamp J, Ambekar S, Hussain T, Mair G, Beck J, Absalon S
bioRxiv
. 2024 Feb;
PMID: 38405843
Plasmodium parasites, which are the causative agents of malaria, undergo closed mitosis without breakdown of the nuclear envelope. Unlike the closed mitosis in yeast, P. berghei parasites undergo multiple rounds...
3.
Fierro M, Muheljic A, Sha J, Wohlschlegel J, Beck J
mSphere
. 2024 Feb;
9(2):e0039323.
PMID: 38334391
Obligate intracellular malaria parasites dramatically remodel their erythrocyte host through effector protein export to create a niche for survival. Most exported proteins contain a pentameric port ement (PEXEL)/host-targeting motif that...
4.
Fierro M, Hussain T, Campin L, Beck J
Proc Natl Acad Sci U S A
. 2023 Aug;
120(33):e2308676120.
PMID: 37552754
Malaria parasites uniquely depend on protein secretion for their obligate intracellular lifestyle but approaches for dissecting -secreted protein functions are limited. We report knockER, a unique DiCre-mediated knock-sideways approach to...
5.
Fierro M, Muheljic A, Sha J, Wohlschlegel J, Beck J
bioRxiv
. 2023 Jul;
PMID: 37503245
Importance: Host erythrocyte remodeling by malaria parasite exported effector proteins is critical to parasite survival and disease pathogenesis. In the deadliest malaria parasite , most exported proteins undergo proteolytic maturation...
6.
Hussain T, Linera-Gonzalez J, Beck J, Fierro M, Mair G, Smith R, et al.
mBio
. 2022 Nov;
13(6):e0309622.
PMID: 36445080
During vertebrate infection, obligate intracellular malaria parasites develop within a parasitophorous vacuole, which constitutes the interface between the parasite and its hepatocyte or erythrocyte host cells. To traverse this barrier,...
7.
Chheda P, Nieto N, Kaur S, Beck J, Beck J, Honzatko R, et al.
Eur J Med Chem
. 2022 Oct;
243:114751.
PMID: 36191407
Malaria is caused by the parasite Plasmodium falciparum, which contains an essential non-photosynthetic plastid called the apicoplast. A single DNA polymerase, apPOL, is targeted to the apicoplast, where it replicates...
8.
Ambekar S, Beck J, Mair G
mBio
. 2022 Aug;
13(5):e0181522.
PMID: 36040030
Twenty years since the publication of the Plasmodium falciparum and P. berghei genomes one-third of their protein-coding genes still lack functional annotation. In the absence of sequence and structural homology,...
9.
Kaur S, Nieto N, McDonald P, Beck J, Honzatko R, Roy A, et al.
J Enzyme Inhib Med Chem
. 2022 May;
37(1):1320-1326.
PMID: 35514163
Malaria is caused by infection with protozoan parasites of the genus, which is part of the phylum Apicomplexa. Most organisms in this phylum contain a relic plastid called the apicoplast....
10.
Ahiya A, Bhatnagar S, Morrisey J, Beck J, Vaidya A
Microbiol Spectr
. 2022 Feb;
10(1):e0015822.
PMID: 35196803
Cholesterol is the most abundant lipid in the erythrocyte. During its blood-stage development, the malaria parasite establishes an active cholesterol gradient across the various membrane systems within the infected erythrocyte....