Simon S McDade
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Explore the profile of Simon S McDade including associated specialties, affiliations and a list of published articles.
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51
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1308
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Recent Articles
1.
McCabe A, Quinn G, Jain S, O Dalaigh M, Dean K, Murphy R, et al.
BMC Bioinformatics
. 2024 Nov;
25(1):362.
PMID: 39574035
Background: Advances in transcriptional profiling methods have enabled the discovery of molecular subtypes within and across traditional tissue-based cancer classifications. Such molecular subgroups hold potential for improving patient outcomes by...
2.
Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
Chatterjee S, Naeli P, Onar O, Simms N, Garzia A, Hackett A, et al.
Nucleic Acids Res
. 2024 Oct;
52(20):12534-12548.
PMID: 39351862
Ribosome quality control (RQC) resolves collided ribosomes, thus preventing their cytotoxic effects. The chemotherapeutic agent 5-Fluorouracil (5FU) is best known for its misincorporation into DNA and inhibition of thymidylate synthase....
3.
Abed A, Greene M, Alsad A, Lees A, Hindley A, Longley D, et al.
Mol Pharm
. 2024 Feb;
21(3):1246-1255.
PMID: 38334409
Inhibitors of the p53-MDM2 interaction such as RG7388 have been developed to exploit latent tumor suppressive properties in p53 in 50% of tumors in which p53 is wild-type. However, these...
4.
Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors
Roy Chaudhuri T, Lin Q, Stachowiak E, Rosario S, Spernyak J, Ma W, et al.
Clin Cancer Res
. 2024 Jan;
30(7):1367-1381.
PMID: 38270582
Purpose: Paracrine activation of pro-fibrotic hedgehog (HH) signaling in pancreatic ductal adenocarcinoma (PDAC) results in stromal amplification that compromises tumor drug delivery, efficacy, and patient survival. Interdiction of HH-mediated tumor-stroma...
5.
Sessler T, Quinn G, Wappett M, Rogan E, Sharkey D, Ahmaderaghi B, et al.
Sci Rep
. 2023 Dec;
13(1):22093.
PMID: 38086891
Kaplan-Meier (KM) survival analyses based on complex patient categorization due to the burgeoning volumes of genomic, molecular and phenotypic data, are an increasingly important aspect of the biomedical researcher's toolkit....
6.
Taylor K, Zou J, Magalhaes M, Oliva M, Spreafico A, Hansen A, et al.
Eur J Cancer
. 2023 May;
188:29-38.
PMID: 37182343
Purpose: Immune checkpoint blockade (ICB) has become a standard of care in the treatment of recurrent/metastatic head and neck squamous cell cancer (R/M HNSCC). However, only a subset of patients...
7.
Steiner I, Flores-Tellez T, Mevel R, Ali A, Wang P, Schofield P, et al.
Cell Rep
. 2023 Apr;
42(4):112377.
PMID: 37060563
The emergence of castration-resistant prostate cancer remains an area of unmet clinical need. We recently identified a subpopulation of normal prostate progenitor cells, characterized by an intrinsic resistance to androgen...
8.
Khawaja H, Briggs R, Latimer C, Rassel M, Griffin D, Hanson L, et al.
Mol Cancer Ther
. 2022 Oct;
22(1):135-149.
PMID: 36279564
Novel covalent inhibitors of KRASG12C have shown limited response rates in patients with KRASG12C-mutant (MT) colorectal cancer. Thus, novel KRASG12C inhibitor combination strategies that can achieve deep and durable responses...
9.
Corry S, McCorry A, Lannagan T, Leonard N, Fisher N, Byrne R, et al.
Gut
. 2022 Apr;
71(12):2502-2517.
PMID: 35477539
Objective: Stroma-rich tumours represent a poor prognostic subtype in stage II/III colon cancer (CC), with high relapse rates and limited response to standard adjuvant chemotherapy. Design: To address the lack...
10.
Quinn G, Sessler T, Ahmaderaghi B, Lambe S, Vansteenhouse H, Lawler M, et al.
BMC Bioinformatics
. 2022 Apr;
23(1):114.
PMID: 35361119
Background: Transcriptionally informed predictions are increasingly important for sub-typing cancer patients, understanding underlying biology and to inform novel treatment strategies. For instance, colorectal cancers (CRCs) can be classified into four...