Daniel A Beard
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Explore the profile of Daniel A Beard including associated specialties, affiliations and a list of published articles.
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149
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2707
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Recent Articles
1.
Jezek F, Baker A, Nordsletten D, Beard D
bioRxiv
. 2025 Mar;
PMID: 40060459
Key Points: 1Passive stress relaxation of cardiac muscle follows a power-law decay, a phenomenon that is explained using a theoretical model of dynamic unfolding of globular domains along polymer chain.The...
2.
Baker A, Li O, Jezek F, Simpson P, Chesler N, Beard D
bioRxiv
. 2025 Mar;
PMID: 40060454
New And Noteworthy: Ca is well-known to trigger activation of muscle contraction. This study demonstrates a new mechanical role for Ca in cardiac muscle involving a >6-fold increase in the...
3.
Gu F, Meyer A, Jezek F, Zhang S, Catalan T, Miller A, et al.
NPJ Digit Med
. 2025 Feb;
8(1):110.
PMID: 39966509
Heart failure (HF) is a highly heterogeneous condition, and current methods struggle to synthesize extensive clinical data for personalized care. Using data from 343 HF patients, we developed mechanistic computational...
4.
Wang H, Kazaleh M, Gioscia-Ryan R, Millar J, Temprano-Sagrera G, Wood S, et al.
bioRxiv
. 2024 Nov;
PMID: 39554010
Abdominal aortic aneurysms (AAAs) are a degenerative aortic disease and associated with hallmarks of aging, such as mitophagy. Despite this, the exact associations among mitophagy, aging, and AAA progression remain...
5.
Teitgen A, Hock M, McCabe K, Childers M, Huber G, Marzban B, et al.
Proc Natl Acad Sci U S A
. 2024 Aug;
121(35):e2322077121.
PMID: 39172779
2'-deoxy-ATP (dATP) improves cardiac function by increasing the rate of crossbridge cycling and Ca[Formula: see text] transient decay. However, the mechanisms of these effects and how therapeutic responses to dATP...
6.
Colebank M, Oomen P, Witzenburg C, Grosberg A, Beard D, Husmeier D, et al.
Am J Physiol Heart Circ Physiol
. 2024 Jun;
327(2):H473-H503.
PMID: 38904851
Computational, or in silico, models are an effective, noninvasive tool for investigating cardiovascular function. These models can be used in the analysis of experimental and clinical data to identify possible...
7.
Kuppa A, Alzamrooni A, Lopez R, Suhan T, Chaudhary R, Collins N, et al.
bioRxiv
. 2024 Jun;
PMID: 38826249
Graphical Abstract:
8.
Sturgess V, Tune J, Figueroa C, Carlson B, Beard D
J Mol Cell Cardiol
. 2024 May;
192:94-108.
PMID: 38754551
While exercise-mediated vasoregulation in the myocardium is understood to be governed by autonomic, myogenic, and metabolic-mediated mechanisms, we do not yet understand the spatial heterogeneity of vasodilation or its effects...
9.
Tune J, Warne C, Essajee S, Tucker S, Figueroa C, Dick G, et al.
J Mol Cell Cardiol
. 2024 Apr;
190:82-91.
PMID: 38608928
The coronary circulation has the inherent ability to maintain myocardial perfusion constant over a wide range of perfusion pressures. The phenomenon of pressure-flow autoregulation is crucial in response to flow-limiting...
10.
Lopez-Schenk R, Collins N, Schenk N, Beard D
Compr Physiol
. 2023 Dec;
14(1):5345-5369.
PMID: 38158366
Purine nucleotides play central roles in energy metabolism in the heart. Most fundamentally, the free energy of hydrolysis of the adenine nucleotide adenosine triphosphate (ATP) provides the thermodynamic driving force...