Kalyan C Vinnakota
Overview
Explore the profile of Kalyan C Vinnakota including associated specialties, affiliations and a list of published articles.
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31
Citations
541
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Recent Articles
1.
Dougherty B, Rawls K, Kolling G, Vinnakota K, Wallqvist A, Papin J
Cell Rep
. 2021 Mar;
34(10):108836.
PMID: 33691118
In diseased states, the heart can shift to use different carbon substrates, measured through changes in uptake of metabolites by imaging methods or blood metabolomics. However, it is not known...
2.
Rawls K, Dougherty B, Vinnakota K, Pannala V, Wallqvist A, Kolling G, et al.
Toxicol Appl Pharmacol
. 2021 Jan;
412:115390.
PMID: 33387578
The kidneys are metabolically active organs with importance in several physiological tasks such as the secretion of soluble wastes into the urine and synthesizing glucose and oxidizing fatty acids for...
3.
Pannala V, Vinnakota K, Estes S, Trenary I, OBrien T, Printz R, et al.
Toxicol Sci
. 2019 Nov;
173(2):293-312.
PMID: 31722432
Identifying early indicators of toxicant-induced organ damage is critical to provide effective treatment. To discover such indicators and the underlying mechanisms of toxicity, we used gentamicin as an exemplar kidney...
4.
Rawls K, Blais E, Dougherty B, Vinnakota K, Pannala V, Wallqvist A, et al.
Toxicol Sci
. 2019 Sep;
172(2):279-291.
PMID: 31501904
Context-specific GEnome-scale metabolic Network REconstructions (GENREs) provide a means to understand cellular metabolism at a deeper level of physiological detail. Here, we use transcriptomics data from chemically-exposed rat hepatocytes to...
5.
Pannala V, Vinnakota K, Rawls K, Estes S, OBrien T, Printz R, et al.
Toxicol Appl Pharmacol
. 2019 Apr;
372:19-32.
PMID: 30974156
Acetaminophen (APAP) is the most commonly used analgesic and antipyretic drug in the world. Yet, it poses a major risk of liver injury when taken in excess of the therapeutic...
6.
Vinnakota K, Pannala V, Wall M, Rahim M, Estes S, Trenary I, et al.
Front Physiol
. 2019 Mar;
10:161.
PMID: 30881311
The liver-a central metabolic organ that integrates whole-body metabolism to maintain glucose and fatty-acid regulation, and detoxify ammonia-is susceptible to injuries induced by drugs and toxic substances. Although plasma metabolite...
7.
Pannala V, Wall M, Estes S, Trenary I, OBrien T, Printz R, et al.
Sci Rep
. 2018 Aug;
8(1):11678.
PMID: 30076366
In order to provide timely treatment for organ damage initiated by therapeutic drugs or exposure to environmental toxicants, we first need to identify markers that provide an early diagnosis of...
8.
Moxley M, Vinnakota K, Bazil J, Qi N, Beard D
PLoS Comput Biol
. 2018 Feb;
14(2):e1005982.
PMID: 29474500
High capacity and low capacity running rats, HCR and LCR respectively, have been bred to represent two extremes of running endurance and have recently demonstrated disparities in fuel usage during...
9.
Liu A, Philip J, Vinnakota K, Van den Bergh F, Tabima D, Hacker T, et al.
Physiol Rep
. 2017 Mar;
5(6).
PMID: 28320896
The typical cause of death in pulmonary hypertension (PH) is right ventricular (RV) failure, with females showing better survival rates than males. Recently, metabolic shift and mitochondrial dysfunction have been...
10.
Tewari S, Bugenhagen S, Vinnakota K, Rice J, Janssen P, Beard D
J Mol Cell Cardiol
. 2016 Apr;
94:162-175.
PMID: 27085901
Alterations in energetic state of the myocardium are associated with decompensated heart failure in humans and in animal models. However, the functional consequences of the observed changes in energetic state...