Dan E McNamara
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Explore the profile of Dan E McNamara including associated specialties, affiliations and a list of published articles.
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13
Citations
490
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Recent Articles
1.
Singh G, Guibao C, Seetharaman J, Aggarwal A, Grace C, McNamara D, et al.
Nat Commun
. 2022 Jan;
13(1):250.
PMID: 35017502
BCL-2 proteins regulate mitochondrial poration in apoptosis initiation. How the pore-forming BCL-2 Effector BAK is activated remains incompletely understood mechanistically. Here we investigate autoactivation and direct activation by BH3-only proteins,...
2.
Laniado J, Cannon K, Miller J, Sawaya M, McNamara D, Yeates T
ACS Nano
. 2021 Mar;
15(3):4277-4286.
PMID: 33683103
Protein molecules bring a rich functionality to the field of designed nanoscale architectures. High-symmetry protein cages are rapidly finding diverse applications in biomedicine, nanotechnology, and imaging, but methods for their...
3.
McNamara D, Dovey C, Hale A, Quarato G, Grace C, Guibao C, et al.
Cell Chem Biol
. 2019 Apr;
26(6):863-877.e7.
PMID: 31031142
Necroptosis is an inflammatory form of programmed cell death executed through plasma membrane rupture by the pseudokinase mixed lineage kinase domain-like (MLKL). We previously showed that MLKL activation requires metabolites...
4.
McNamara D, Quarato G, Guy C, Green D, Moldoveanu T
J Vis Exp
. 2018 Aug;
(138).
PMID: 30148498
Necroptosis is a programmed cell death pathway triggered by activation of receptor interacting protein kinase 3 (RIPK3), which phosphorylates and activates the mixed lineage kinase-like domain pseudokinase, MLKL, to rupture...
5.
Dovey C, Diep J, Clarke B, Hale A, McNamara D, Guo H, et al.
Mol Cell
. 2018 Jun;
70(5):936-948.e7.
PMID: 29883610
Necroptosis is an important form of lytic cell death triggered by injury and infection, but whether mixed lineage kinase domain-like (MLKL) is sufficient to execute this pathway is unknown. In...
6.
Zheng J, Grace C, Guibao C, McNamara D, Llambi F, Wang Y, et al.
Cell Rep
. 2018 May;
23(7):2083-2094.e6.
PMID: 29768206
The effector B cell lymphoma-2 (BCL-2) protein BCL-2 ovarian killer (BOK) induces mitochondrial outer membrane permeabilization (MOMP) to initiate apoptosis upon inhibition of the proteasome. How BOK mediates MOMP is...
7.
Fallas J, Ueda G, Sheffler W, Nguyen V, McNamara D, Sankaran B, et al.
Nat Chem
. 2017 Mar;
9(4):353-360.
PMID: 28338692
Self-assembling cyclic protein homo-oligomers play important roles in biology, and the ability to generate custom homo-oligomeric structures could enable new approaches to probe biological function. Here we report a general...
8.
McNamara D, Senese S, Yeates T, Torres J
Protein Sci
. 2015 May;
24(7):1164-72.
PMID: 25970265
Small molecules that bind to tubulin exert powerful effects on cell division and apoptosis (programmed cell death). Cell-based high-throughput screening combined with chemo/bioinformatic and biochemical analyses recently revealed a novel...
9.
King N, Bale J, Sheffler W, McNamara D, Gonen S, Gonen T, et al.
Nature
. 2014 May;
510(7503):103-8.
PMID: 24870237
The self-assembly of proteins into highly ordered nanoscale architectures is a hallmark of biological systems. The sophisticated functions of these molecular machines have inspired the development of methods to engineer...
10.
Sinha S, Cheng S, Sung Y, McNamara D, Sawaya M, Yeates T, et al.
J Mol Biol
. 2014 Apr;
426(12):2328-45.
PMID: 24747050
Bacterial microcompartments (MCPs) are the simplest organelles known. They function to enhance metabolic pathways by confining several related enzymes inside an all-protein envelope called the shell. In this study, we...