Tudor Moldoveanu
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Explore the profile of Tudor Moldoveanu including associated specialties, affiliations and a list of published articles.
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40
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2627
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Recent Articles
1.
Ruhl S, Li Z, Srivastava S, Mari L, Guy C, Yang M, et al.
Cell Death Differ
. 2024 Oct;
32(2):320-336.
PMID: 39406920
BCL-2 family proteins regulate apoptosis by initiating mitochondrial outer membrane permeabilization (MOMP). Activation of the MOMP effectors BAX and BAK is controlled by the interplay of anti-apoptotic BCL-2 proteins (e.g.,...
2.
Wright T, Turnis M, Grace C, Li X, Brakefield L, Wang Y, et al.
Mol Cell
. 2024 Mar;
84(7):1338-1353.e8.
PMID: 38503284
MCL-1 is essential for promoting the survival of many normal cell lineages and confers survival and chemoresistance in cancer. Beyond apoptosis regulation, MCL-1 has been linked to modulating mitochondrial metabolism,...
3.
Moldoveanu T
Bioessays
. 2023 Jan;
45(3):e2200221.
PMID: 36650950
The pore-forming BCL-2 family proteins are effectors of mitochondrial poration in apoptosis initiation. Two atypical effectors-BOK and truncated BID (tBID)-join the canonical effectors BAK and BAX. Gene knockout revealed developmental...
4.
Chen P, Han X, Shaw T, Fu Y, Sun H, Niu M, et al.
Nat Aging
. 2023 Jan;
2(10):923-940.
PMID: 36636325
Recent proteome and transcriptome profiling of Alzheimer's disease (AD) brains reveals RNA splicing dysfunction and U1 small nuclear ribonucleoprotein (snRNP) pathology containing U1-70K and its N-terminal 40-KDa fragment (N40K). Here...
5.
Sekar G, Singh G, Qin X, Guibao C, Schwam B, Inde Z, et al.
iScience
. 2022 Sep;
25(10):105064.
PMID: 36147946
Poration of the outer mitochondrial membrane by the effector BCL-2 proteins BAK and BAX initiates apoptosis. BH3-only initiators BID and BIM trigger conformational changes in BAK and BAX transforming them...
6.
Sekar G, Ojoawo A, Moldoveanu T
Biochem Soc Trans
. 2022 May;
50(3):1091-1103.
PMID: 35521828
Apoptosis is a common cell death program that is important in human health and disease. Signaling in apoptosis is largely driven through protein-protein interactions. The BCL-2 family proteins function in...
7.
Singh G, Guibao C, Seetharaman J, Aggarwal A, Grace C, McNamara D, et al.
Nat Commun
. 2022 Jan;
13(1):250.
PMID: 35017502
BCL-2 proteins regulate mitochondrial poration in apoptosis initiation. How the pore-forming BCL-2 Effector BAK is activated remains incompletely understood mechanistically. Here we investigate autoactivation and direct activation by BH3-only proteins,...
8.
Ojoawo A, Moldoveanu T
EMBO J
. 2021 Sep;
40(20):e109529.
PMID: 34542920
Permeabilization of the outer mitochondrial membrane initiates apoptotic cell death. B-cell lymphoma 2 (BCL-2) antagonist killer (BAK) and BCL-2-associated X (BAX) mediate mitochondrial poration, but how this process unfolds remains...
9.
Schnetler R, Fanucchi S, Moldoveanu T, Koorsen G
Biochemistry
. 2020 Aug;
59(36):3332-3346.
PMID: 32786407
H1.2 is a key mediator of apoptosis following DNA double-strand breaks. The link between H1.2 and canonical apoptotic pathways is unclear. One study found that H1.2 stimulates cytochrome (Cyt )...
10.
Guibao C, Petrinjak K, Moldoveanu T
Future Med Chem
. 2019 Nov;
11(21):2831-2844.
PMID: 31713433
MLKL and its obligate upstream receptor interacting protein kinase 3 are essential components of necroptosis. It is well established that MLKL is the executioner of plasma membrane rupture in necroptosis....