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Dahong Long

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Articles 26
Citations 701
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Recent Articles
1.
Xu L, Liu Y, Long J, He X, Xie F, Yin Q, et al.
Mol Psychiatry . 2023 Jul; 28(8):3444-3458. PMID: 37500828
Adverse experiences in early life can shape neuronal structures and synaptic function in multiple brain regions, leading to deficits of distinct cognitive functions later in life. Focusing on the pyramidal...
2.
Lyu Y, Su Z, Ye G, He X, Liu Y, Yin Q, et al.
Exp Gerontol . 2023 Jun; 179:112243. PMID: 37336370
The differentiation of human induced pluripotent stem cells (hiPSCs) into functional dopaminergic neural precursors is the basis of cell therapy for Parkinson's disease (PD). However, the use of small molecule...
3.
Xu B, He Y, Liu L, Ye G, Chen L, Wang Q, et al.
Aging Dis . 2022 Jul; 13(4):1293-1310. PMID: 35855335
Memory loss is the key symptom of Alzheimer's disease (AD). As successful drug treatments have not yet been identified, non-pharmaceutical interventions such as physical exercise and training have been employed...
4.
He Y, Xu B, Chen Y, Liu L, Xu L, Chen Y, et al.
Brain Struct Funct . 2021 Jan; 226(2):397-414. PMID: 33386419
The effects of early-life adversity (ELA) on dendritic differentiation of striatal neurons were investigated in the dorsal striatum including the dorsomedial striatum and dorsolateral striatum (DMS and DLS, respectively). An...
5.
Zhu Q, Zhang N, Hu N, Jiang R, Lu H, Xuan A, et al.
Mol Med Rep . 2020 Jan; 21(3):1172-1180. PMID: 31922229
Alzheimer's disease (AD) is the most prevalent age‑related neurodegenerative disorder. It is featured by the progressive accumulation of β‑amyloid (Aβ) plaques and neurofibrillary tangles. This can eventually lead to a...
6.
Xu L, Long J, Su Z, Xu B, Lin M, Chen Y, et al.
Neurobiol Dis . 2019 Aug; 132:104586. PMID: 31470103
The effects of prolonged physical training on memory performance and underlying presynaptic mechanisms were investigated in old C57BL/6 mice. Training via voluntary running wheels was initiated at 16 months of...
7.
Gong Z, Huang J, Xu B, Ou Z, Zhang L, Lin X, et al.
J Neuroinflammation . 2019 Mar; 16(1):62. PMID: 30871577
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and impaired neurogenesis. Urolithin A (UA), a gut-microbial metabolite of ellagic...
8.
Kong X, Gong Z, Zhang L, Sun X, Ou Z, Xu B, et al.
Brain Behav Immun . 2019 Feb; 79:159-173. PMID: 30763768
Neuroinflammation, considered as a pathological hallmark of Alzheimer's disease (AD), has been demonstrated to affect hippocampal neurogenesis and cognitive function. Interleukin-6 (IL-6) is a proinflammatory cytokine known to modulate neurogenesis....
9.
He X, Liu Y, Lin X, Yuan F, Long D, Zhang Z, et al.
J Neuroinflammation . 2018 Sep; 15(1):268. PMID: 30227858
Background: Netrin-1 functions largely via combined receptors and downstream effectors. Evidence has shown that astrocytes express netrin-1 receptors, including DCC and UNC5H2. However, whether netrin-1 influences the function of astrocytes...
10.
Xu B, Sun A, He Y, Qian F, Xi S, Long D, et al.
Neurobiol Aging . 2018 Aug; 71:91-104. PMID: 30118927
Aging is a normal physiological process associated with impairments in cognitive function, including learning and memory. Here, the underlying synaptic mechanisms by which aging leads to the decline of spatial...