D W Robertson
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Explore the profile of D W Robertson including associated specialties, affiliations and a list of published articles.
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106
Citations
1047
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Recent Articles
1.
Bymaster F, Beedle E, Findlay J, Gallagher P, Krushinski J, Mitchell S, et al.
Bioorg Med Chem Lett
. 2003 Dec;
13(24):4477-80.
PMID: 14643350
A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be...
2.
Roberds S, Anderson J, Basi G, Bienkowski M, Branstetter D, Chen K, et al.
Hum Mol Genet
. 2001 Jun;
10(12):1317-24.
PMID: 11406613
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. The major components of plaque, beta-amyloid peptides (Abetas), are produced from...
3.
Hicks L, Lin Y, Robertson D, Robinson D, Woodrow S
BMJ
. 2001 Mar;
322(7288):709-10.
PMID: 11264209
No abstract available.
4.
Gilligan P, Baldauf C, Cocuzza A, Chidester D, Zaczek R, Fitzgerald L, et al.
Bioorg Med Chem
. 2000 Sep;
8(1):181-9.
PMID: 10968277
Structure activity relationship studies led to the discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazo lo-[1,5-a]-pyrimidine 11-31 (DMP904), whose pharmacological profile strongly supports the hypothesis that hCRF1 antagonists may be potent anxiolytic drugs. Compound 11-31...
5.
Seiffert D, Bradley J, Rominger C, Rominger D, Yang F, Meredith Jr J, et al.
J Biol Chem
. 2000 Aug;
275(44):34086-91.
PMID: 10915801
Presenilins are integral membrane protein involved in the production of amyloid beta-protein. Mutations of the presenilin-1 and -2 gene are associated with familial Alzheimer's disease and are thought to alter...
6.
Gilligan P, Robertson D, Zaczek R
J Med Chem
. 2000 May;
43(9):1641-60.
PMID: 10794681
No abstract available.
7.
Fitzgerald L, Burn T, Brown B, Patterson J, Corjay M, VALENTINE P, et al.
Mol Pharmacol
. 2000 Jan;
57(1):75-81.
PMID: 10617681
Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant until it was reported to be associated with valvular heart disease. The valvular changes (myofibroblast proliferation)...
8.
Robertson D
J Med Ethics
. 1996 Oct;
22(5):292-9.
PMID: 8910782
Objectives: To study empirically whether ethical theory (from the mainstream principles-based, virtue-based, and feminist schools) usefully describes the approaches doctors and nurses take in everyday patient care. Design: Ethnographic methods:...
9.
Ashikaga T, Robertson D, Sportsman R, Strada S, Thompson W
J Recept Signal Transduct Res
. 1996 Sep;
16(5-6):315-37.
PMID: 8968964
Dihydropyridazinone(DHP) derivatives such as indolidan are positive inotropic agents that show inhibition of cyclic AMP phosphodiesterase(PDE) activity. Indolidan inhibition is selective for PDE3 among the seven PDE gene families. DHP...
10.
Engleman E, Robertson D, Thompson D, Perry K, Wong D
J Neurochem
. 1996 Feb;
66(2):599-603.
PMID: 8592129
In the current study we examined the effects of coadministration of a serotonin 5-HT1A antagonist, (+-)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)-2-propanol maleate (LY 206130), and a dual 5-HT and norepinephrine (NE) uptake inhibitor, duloxetine, on...