D W Robertson
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Explore the profile of D W Robertson including associated specialties, affiliations and a list of published articles.
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106
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1047
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Recent Articles
11.
Gidda J, Evans D, Cohen M, Wong D, Robertson D, Parli C
J Pharmacol Exp Ther
. 1995 May;
273(2):695-701.
PMID: 7752072
Recently discovered serotonin3 (5-HT3) receptor antagonists are potent antiemetics in cytotoxic drug-induced vomiting. The specific site where 5-HT3 receptor antagonists act to abolish emesis is controversial. The major objective of...
12.
Gehlert D, Schober D, Hemrick-Luecke S, Krushinski J, Howbert J, Robertson D, et al.
Neurochem Int
. 1995 Jan;
26(1):47-52.
PMID: 7787762
Halogenated analogs of the potent norepinephrine (NE) uptake inhibitor, tomoxetine, were synthesized and their affinities for the serotonin (5HT) and NE uptake sites evaluated. One of the most potent was...
13.
(R)-thionisoxetine, a potent and selective inhibitor of central and peripheral norepinephrine uptake
Gehlert D, Hemrick-Luecke S, Schober D, Krushinski J, Howbert J, Robertson D, et al.
Life Sci
. 1995 Jan;
56(22):1915-20.
PMID: 7746100
Inhibitors of neuronal norepinephrine (NE) uptake are useful for the treatment of a variety of diseases including depression and urinary incontinence. In the present study, we synthesized and evaluated a...
14.
Gehlert D, Robertson D
Prog Neuropsychopharmacol Biol Psychiatry
. 1994 Nov;
18(7):1093-102.
PMID: 7846282
1. K channels are a diverse and ubiquitous class of proteins that regulate a number of biological functions. 2. Ligands for the study of a variety of K channels are...
15.
Walter Jr J, Galitz J, Robertson D
J Am Podiatr Med Assoc
. 1994 Nov;
84(11):574-7.
PMID: 7807386
Although pigmented villonodular synovitis is a benign process, the potential of osseous destruction makes it a difficult case to manage. The treatment of pigmented villonodular synovitis often necessitates multiple surgical...
16.
Cohen M, Susemichel A, Bloomquist W, Robertson D
Gen Pharmacol
. 1994 Oct;
25(6):1143-8.
PMID: 7875537
1. Marked heterogeneity among species exists in the esophageal response to pharmacological agents. The present study compared the response to serotonin in esophagus from the rat, guinea pig, rabbit and...
17.
Kohn H, Sawhney K, Robertson D, Leander J
J Pharm Sci
. 1994 May;
83(5):689-91.
PMID: 8071822
Recent studies have demonstrated that functionalized alpha,alpha-diamino acids (1) display excellent activity when evaluated in the maximal electroshock seizure (MES) test in mice. The synthesis and pharmacological evaluation of 14...
18.
Velez P, Robertson D
Endosc Surg Allied Technol
. 1994 Apr;
2(2):155-60.
PMID: 8081935
With the increased use of laparoscopic surgery and the obligatory loss of palpation of solid organs, laparoscopic ultrasound will be an invaluable tool for the location and evaluation of solid...
19.
Kohn H, Sawhney K, Bardel P, Robertson D, Leander J
J Med Chem
. 1993 Oct;
36(22):3350-60.
PMID: 8230125
Earlier studies showed that (R,S)-alpha-acetamido-N-benzylacetamides (2) containing a five- and six-membered aromatic or heteroaromatic group appended at the C(alpha) site displayed outstanding activity in the maximal electroshock-induced seizure (MES) test...
20.
Synthesis and evaluation of [125I]-(S)-iodozacopride, a high affinity radioligand for 5HT3 receptors
Gehlert D, Schober D, Gackenheimer S, Mais D, Ladouceur G, Robertson D
Neurochem Int
. 1993 Oct;
23(4):373-83.
PMID: 8220179
We have developed a high specific activity radioiodinated ligand for the biochemical evaluation and autoradiographic localization of 5HT3 receptors in the brain. [125I]-(S)-iodozacopride was synthesized by radioiodination of deschloro-(S)-zacopride using...