D Hazuda
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Explore the profile of D Hazuda including associated specialties, affiliations and a list of published articles.
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22
Citations
591
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Recent Articles
11.
Li Y, Yan Y, Xu B, Cole J, Witmer M, Felock P, et al.
Acta Crystallogr D Biol Crystallogr
. 1999 Oct;
55(Pt 11):1906-10.
PMID: 10531491
The C-terminal two-thirds segment of integrase derived from the simian immunodeficiency virus has been cloned, expressed in Escherichia coli, and purified to greater than 95% homogeneity. The protein encompasses amino-acid...
12.
Goodarzi G, Pursley M, Felock P, Witmer M, Hazuda D, Brackmann K, et al.
J Virol
. 1999 Sep;
73(10):8104-11.
PMID: 10482559
Full-site integration by recombinant wild-type and mutant simian immunodeficiency virus (SIV) integrase (IN) was investigated with linear retrovirus-like DNA (469 bp) as a donor substrate and circular DNA (2,867 bp)...
13.
Flores O, Lee G, Kessler J, Miller M, Schlief W, Tomassini J, et al.
Proc Natl Acad Sci U S A
. 1999 Jun;
96(13):7208-13.
PMID: 10377393
HIV-1 gene expression and viral replication require the viral transactivator protein Tat. The RNA polymerase II transcriptional elongation factor P-TEFb (cyclin-dependent kinase 9/cyclin T) is a cellular protein kinase that...
14.
Hazuda D, Blau C, Felock P, Hastings J, Pramanik B, Wolfe A, et al.
Antivir Chem Chemother
. 1999 May;
10(2):63-70.
PMID: 10335400
We have identified a series of novel inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase by randomly screening natural product extracts using an in vitro biochemical assay designed to...
15.
Mancebo H, Lee G, Flygare J, Tomassini J, Luu P, Zhu Y, et al.
Genes Dev
. 1997 Oct;
11(20):2633-44.
PMID: 9334326
To identify novel inhibitors of transcriptional activation by the HIV Tat protein, we used a combination of in vitro and in vivo Tat-dependent transcription assays to screen >100,000 compounds. All...
16.
17.
Hazuda D, Felock P, Hastings J, Pramanik B, Wolfe A
Drug Des Discov
. 1997 May;
15(1):17-24.
PMID: 9332828
An essential step in the replication of retroviruses is the integration of a DNA copy of the viral genome into the genome of the host cell. Integration encompasses a series...
18.
Hazuda D, Felock P, Hastings J, Pramanik B, Wolfe A, Goodarzi G, et al.
J Virol
. 1997 Jan;
71(1):807-11.
PMID: 8985421
In vitro assay systems which use recombinant retroviral integrase (IN) and short DNA oligonucleotides fail to recapitulate the full-site integration reaction as it is known to occur in vivo. The...
19.
20.
Tomassini J, Selnick H, Davies M, Armstrong M, Baldwin J, Bourgeois M, et al.
Antimicrob Agents Chemother
. 1994 Dec;
38(12):2827-37.
PMID: 7695269
Synthesis of influenza virus mRNA is primed by capped and methylated (cap 1, m7GpppXm) RNAs which the virus derives by endonucleolytic cleavage from RNA polymerase II transcripts in host cells....