D H Caignard
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Explore the profile of D H Caignard including associated specialties, affiliations and a list of published articles.
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26
Citations
72
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Recent Articles
1.
Yous S, Poupaert J, Chavatte P, Espiard J, Caignard D, Lesieur D
Drug Des Discov
. 2002 Jan;
17(4):331-6.
PMID: 11765136
A series of novel 6-substituted-2(3H)-benzothiazolones were synthesized and studied as analgesic agents. Among these compounds, two of them were found to exhibit potent analgesic activity in several in vivo tests...
2.
Capilla A, Sanchez I, Caignard D, Renard P, Pujol M
Eur J Med Chem
. 2001 Jul;
36(4):389-93.
PMID: 11461764
New compounds with naphtho-fused systems were synthesized and evaluated as antitumor agents. The naphtho-fused systems 6 and 7, synthesized from the hydroxy-acetal, exhibit antitumor activity. The bis(phenylthio) derivatives were considered...
3.
Wu J, Shan F, Wu G, Li Y, Ding J, Xiao D, et al.
Eur J Med Chem
. 2001 Jul;
36(5):469-79.
PMID: 11451535
A series of 12alpha-deoxoartemisinyl cyanoarylmethyl dicarboxylates (4a-4o), dicarboxylic acids 12alpha-deoxoartemisinyl ester cyanoarylmethyl amide (5a-5k), and dicarboxylic acids 12alpha-deoxoartemisinyl ester N-methylcyanoarylmethyl amide (6a-6l), showing moderate cytotoxicity against P388 and L1210 cells...
4.
Anastassiadou M, Danoun S, Crane L, Payard M, Caignard D, Rettori M, et al.
Bioorg Med Chem
. 2001 Apr;
9(3):585-92.
PMID: 11310592
Several series of 2-aryl or heterocyclic-imidazoline compounds have been prepared and evaluated in vitro as imidazoline sites (I1 and I2) and alpha-adrenergic (alpha1 and alpha2) receptor ligands. Their pKi values...
5.
Kostakis I, Ghirtis K, Pouli N, Marakos P, Skaltsounis A, Leonce S, et al.
Farmaco
. 2001 Feb;
55(6-7):455-60.
PMID: 11204746
The synthesis and biological evaluation of some new pyranoxanthenones and pyranothioxanthenones, substituted with flexible amino side-chains, and their evaluation as potential antitumor agents is described. The cytotoxic activity of the...
6.
Li Y, Shan F, Wu J, Wu G, Ding J, Xiao D, et al.
Bioorg Med Chem Lett
. 2001 Jan;
11(1):5-8.
PMID: 11140731
Modification of artemisinin structure led us to the discovery of a novel class of antitumor compounds. These artemisinin derivatives containing cyano and aryl groups showed potent antiproliferative effect in vitro...
7.
Carato P, Depreux P, Lesieur D, Millan M, Newman-Tancredi A, Rettori M, et al.
Drug Des Discov
. 2000 Oct;
17(2):173-81.
PMID: 11045903
A series of new arylpiperazinomethyl derivatives was designed and studied as potential D4 ligands. The synthesis of these compounds required an original synthetic route. Some of the tested compounds were...
8.
Labssita Y, Payard M, Caignard D, Rubat C
Ann Pharm Fr
. 2000 Aug;
58(4):254-9.
PMID: 10915973
The synthesis of 44 original amide derivatives of benzylpiperazine and some analogues of befuraline and piberaline is reported. All compounds have been tested as antidepressive agents. According to the tests,...
9.
Ansar M, Ebrik S, Mouhoub R, Vaccher C, Vaccher M, Flouquet N, et al.
Therapie
. 2000 Feb;
54(5):651-8.
PMID: 10667104
Baclofen (4-amino-3-(4-chlorophenyl)butyric acid) is the only selective agonist for GABA-B receptors. Its R-(-)-enantiomer is about 100 times more active than the S-(+)-enantiomer. In the search for new compounds that bind...
10.
Bermejo A, Leonce S, Cabedo N, Andreu I, Caignard D, Atassi G, et al.
J Nat Prod
. 1999 Sep;
62(8):1106-9.
PMID: 10479313
The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5-12), were determined in vitro on L-1210 cells. Semisyntheses and structure-activity relationships of these compounds...