D Edelstein
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Explore the profile of D Edelstein including associated specialties, affiliations and a list of published articles.
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45
Citations
3402
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Recent Articles
1.
Vidal J, Muinelo L, Dalmases A, Jones F, Edelstein D, Iglesias M, et al.
Ann Oncol
. 2017 Apr;
28(6):1325-1332.
PMID: 28419195
Background: RAS assessment is mandatory for therapy decision in metastatic colorectal cancer (mCRC) patients. This determination is based on tumor tissue, however, genotyping of circulating tumor (ct)DNA offers clear advantages...
2.
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes
Du X, Edelstein D, Brownlee M
Diabetologia
. 2008 Jul;
51(10):1930-2.
PMID: 18663426
Aims/hypothesis: We determined whether fixed doses of benfotiamine in combination with slow-release alpha-lipoic acid normalise markers of reactive oxygen species-induced pathways of complications in humans. Methods: Male participants with and...
3.
Srinivasan S, Hatley M, Bolick D, Palmer L, Edelstein D, Brownlee M, et al.
Diabetologia
. 2004 Oct;
47(10):1727-34.
PMID: 15490108
Aims/hypothesis: Hyperglycaemia is a primary cause of vascular complications in diabetes. A hallmark of these vascular complications is endothelial cell dysfunction, which is partly due to the reduced production of...
4.
Du X, Edelstein D, Dimmeler S, Ju Q, Sui C, Brownlee M
J Clin Invest
. 2001 Nov;
108(9):1341-8.
PMID: 11696579
Endothelial nitric oxide synthase (eNOS) is activated by phosphorylation of serine 1177 by the protein kinase Akt/PKB. Since hyperglycemia-induced mitochondrial superoxide overproduction increases O-linked N-acetylglucosamine modification and decreases O-linked phosphorylation...
5.
Yamagishi S, Edelstein D, Du X, Brownlee M
Diabetes
. 2001 May;
50(6):1491-4.
PMID: 11375352
Alteration of platelet function contributes to microthrombus formation and may play an important role in the pathogenesis of diabetic micro- and macroangiopathies. However, the molecular mechanism for platelet dysfunction observed...
6.
Yamagishi S, Edelstein D, Du X, Kaneda Y, Guzman M, Brownlee M
J Biol Chem
. 2001 May;
276(27):25096-100.
PMID: 11342529
Leptin, a circulating hormone secreted mainly from adipose tissues, is involved in the control of body weight. The plasma concentrations are correlated with body mass index, and are reported to...
7.
Du X, Edelstein D, Rossetti L, Fantus I, Goldberg H, Ziyadeh F, et al.
Proc Natl Acad Sci U S A
. 2000 Oct;
97(22):12222-6.
PMID: 11050244
The hexosamine pathway has been implicated in the pathogenesis of diabetic complications. We determined first that hyperglycemia induced a decrease in glyceraldehyde-3-phosphate dehydrogenase activity in bovine aortic endothelial cells via...
8.
Nishikawa T, Giardino I, Edelstein D, Brownlee M
Curr Eye Res
. 2000 Oct;
21(1):581-7.
PMID: 11035540
Recently, all the structural features of non-proliferative diabetic retinopathy have been demonstrated in mice fed 30% galactose for 21-26 months. To determine whether changes in retinal matrix protein mRNA levels...
9.
Nishikawa T, Edelstein D, Brownlee M
Kidney Int Suppl
. 2000 Sep;
77:S26-30.
PMID: 10997687
A causal relationship between chronic hyperglycemia and diabetic microvascular disease, long inferred from various animal and clinical studies, has now been definitely established by data from the Diabetes Control and...
10.
Nishikawa T, Edelstein D, Du X, Yamagishi S, Matsumura T, Kaneda Y, et al.
Nature
. 2000 Apr;
404(6779):787-90.
PMID: 10783895
Diabetic hyperglycaemia causes a variety of pathological changes in small vessels, arteries and peripheral nerves. Vascular endothelial cells are an important target of hyperglycaemic damage, but the mechanisms underlying this...