D C Link
Overview
Explore the profile of D C Link including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
1185
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0
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Recent Articles
11.
Betsuyaku T, Liu F, Senior R, Haug J, Brown E, Jones S, et al.
J Clin Invest
. 1999 Mar;
103(6):825-32.
PMID: 10079103
Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that is widely used to treat neutropenia. In addition to stimulating polymorphonuclear neutrophil (PMN) production, G-CSF may have significant effects on...
12.
Zhang P, Iwama A, Datta M, Darlington G, Link D, Tenen D
J Exp Med
. 1998 Sep;
188(6):1173-84.
PMID: 9743535
Cytokines stimulate granulopoiesis through signaling via receptors whose expression is controlled by lineage-specific transcription factors. Previously, we demonstrated that granulocyte colony-stimulating factor (G-CSF) receptor mRNA was undetectable and granulocyte maturation...
13.
McLemore M, Poursine-Laurent J, Link D
J Clin Invest
. 1998 Aug;
102(3):483-92.
PMID: 9691084
The role of mutations of the granulocyte colony-stimulating factor receptor (G-CSFR) in the pathogenesis of severe congenital neutropenia (SCN) and the subsequent development of acute myeloid leukemia (AML) is controversial....
14.
Jacob J, Haug J, Raptis S, Link D
Blood
. 1998 Jul;
92(2):353-61.
PMID: 9657731
Granulocyte colony-stimulating factor (G-CSF) is the principal growth factor regulating the production of neutrophils, yet its role in lineage commitment and terminal differentiation of hematopoietic progenitor cells is controversial. In...
15.
Liu F, Poursine-Laurent J, Wu H, Link D
Blood
. 1997 Nov;
90(7):2583-90.
PMID: 9326224
Multiple hematopoietic cytokines can stimulate granulopoiesis; however, their relative importance in vivo and mechanisms of action remain unclear. We recently reported that granulocyte colony-stimulating factor receptor (G-CSFR)-deficient mice have a...
16.
Liu F, Poursine-Laurent J, Link D
Blood
. 1997 Nov;
90(7):2522-8.
PMID: 9326216
Hematopoietic progenitor cells (HPC) can be mobilized from the bone marrow into the peripheral circulation in response to a number of stimuli including hematopoietic growth factors, cytotoxic agents, and certain...
17.
Liu F, Wu H, Wesselschmidt R, Kornaga T, Link D
Immunity
. 1996 Nov;
5(5):491-501.
PMID: 8934575
We have generated mice carrying a homozygous null mutation in the granulocyte colony-stimulating factor receptor (G-CSFR) gene. G-CSFR-deficient mice have decreased numbers of phenotypically normal circulating neutrophils. Hematopoietic progenitors are...
18.
Rodel J, Link D
Blood
. 1996 Feb;
87(3):858-64.
PMID: 8562953
The role of cytokines in the control of hematopoietic cell differentiation remains controversial. Two general models for the cytokine control of hematopoietic differentiation have been proposed. In the stochastic model,...
19.
Zhou M, Lublin D, Link D, Brown E
J Biol Chem
. 1995 Jun;
270(22):13553-60.
PMID: 7768958
Two tyrosine kinase-dependent pathways exist for activation of the respiratory burst by polymorphonuclear leukocyte (PMN) immunoglobulin G Fc receptors. Direct ligation of Fc gamma RII activates the respiratory burst, but...
20.
Link D, Zutter M
Blood
. 1995 Jan;
85(2):472-9.
PMID: 7812001
The proto-oncogene c-fgr is a member of the c-src gene family of cytoplasmic tyrosine kinases. Previous studies have suggested that it is normally expressed in neutrophils, monocytes, macrophages, and natural...