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J Poursine-Laurent

Explore the profile of J Poursine-Laurent including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 304
Followers 0
Related Specialties
Hematology
Allergy & Immunology
General Medicine
Top 10 Co-Authors
D C Link
F Liu
M L McLemore
H Y Wu
S T Ferris
J Haug
D A Higuchi
W M Yokoyama
P Cahan
J Gao
Published In
Blood
Immunity
Genes Immun
J Clin Invest
Affiliations
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Recent Articles
1.
Structural variation of the mouse natural killer gene complex
Higuchi D, Cahan P, Gao J, Ferris S, Poursine-Laurent J, Graubert T, et al.
Genes Immun . 2010 Sep; 11(8):637-48. PMID: 20861859
The natural killer gene complex (NKC) on chromosome 6 contains clusters of genes that encode both activation and inhibitory receptors expressed on mouse natural killer (NK) cells. NKC genes, particularly...
2.
STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation
McLemore M, Grewal S, Liu F, Archambault A, Poursine-Laurent J, Haug J, et al.
Immunity . 2001 Mar; 14(2):193-204. PMID: 11239451
To investigate the role of signal transducer and activator of transcription (STAT) proteins in granulocyte colony-stimulating factor (G-CSF)-regulated biological responses, we generated transgenic mice with a targeted mutation of their...
3.
Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF
Liu F, Poursine-Laurent J, Link D
Blood . 2000 May; 95(10):3025-31. PMID: 10807765
The mechanisms that regulate hematopoietic progenitor cell (HPC) mobilization from the bone marrow to blood have not yet been defined. HPC mobilization by granulocyte colony-stimulating factor (G-CSF), cyclophosphamide (CY), or...
4.
A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation
Semerad C, Poursine-Laurent J, Liu F, Link D
Immunity . 1999 Sep; 11(2):153-61. PMID: 10485650
To investigate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a targeted mutation of their G-CSF receptor (G-CSFR) such that the cytoplasmic (signaling) domain of the...
5.
Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia
McLemore M, Poursine-Laurent J, Link D
J Clin Invest . 1998 Aug; 102(3):483-92. PMID: 9691084
The role of mutations of the granulocyte colony-stimulating factor receptor (G-CSFR) in the pathogenesis of severe congenital neutropenia (SCN) and the subsequent development of acute myeloid leukemia (AML) is controversial....
6.
Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation
Liu F, Poursine-Laurent J, Wu H, Link D
Blood . 1997 Nov; 90(7):2583-90. PMID: 9326224
Multiple hematopoietic cytokines can stimulate granulopoiesis; however, their relative importance in vivo and mechanisms of action remain unclear. We recently reported that granulocyte colony-stimulating factor receptor (G-CSFR)-deficient mice have a...
7.
The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand
Liu F, Poursine-Laurent J, Link D
Blood . 1997 Nov; 90(7):2522-8. PMID: 9326216
Hematopoietic progenitor cells (HPC) can be mobilized from the bone marrow into the peripheral circulation in response to a number of stimuli including hematopoietic growth factors, cytotoxic agents, and certain...