D C Crick
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Explore the profile of D C Crick including associated specialties, affiliations and a list of published articles.
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24
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462
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Recent Articles
1.
Crick D, Mahapatra S, Brennan P
Glycobiology
. 2001 Sep;
11(9):107R-118R.
PMID: 11555614
The compositional complexity of the mycobacterial cell envelope differentiates Mycobacterium species from most other prokaryotes. Historically, research in this area has focused on the elucidation of the structure of the...
2.
Schulbach M, Mahapatra S, Macchia M, Barontini S, Papi C, Minutolo F, et al.
J Biol Chem
. 2001 Jan;
276(15):11624-30.
PMID: 11152452
We have recently shown that open reading frame Rv1086 of the Mycobacterium tuberculosis H37Rv genome sequence encodes a unique isoprenyl diphosphate synthase. The product of this enzyme, omega,E,Z-farnesyl diphosphate, is...
3.
Mahapatra S, Crick D, Brennan P
J Bacteriol
. 2000 Nov;
182(23):6827-30.
PMID: 11073931
In the peptidoglycan of Mycobacterium leprae, L-alanine of the side chain is replaced by glycine. When expressed in Escherichia coli, MurC (UDP-N-acetyl-muramate:L-alanine ligase) of M. leprae showed K(m) and V(max)...
4.
Crick D, Schulbach M, Zink E, Macchia M, Barontini S, Besra G, et al.
J Bacteriol
. 2000 Sep;
182(20):5771-8.
PMID: 11004176
Mycobacterium smegmatis has been shown to contain two forms of polyprenyl phosphate (Pol-P), while Mycobacterium tuberculosis contains only one. Utilizing subcellular fractions from M. smegmatis and M. tuberculosis, we show...
5.
Mikusova K, Yagi T, Stern R, McNeil M, Besra G, Crick D, et al.
J Biol Chem
. 2000 Aug;
275(43):33890-7.
PMID: 10934214
The structural core of the cell walls of Mycobacterium spp. consists of peptidoglycan bound by a linker unit (-alpha-L-Rhap-(1-->3)-D-GlcNAc-P-) to a galactofuran, which in turn is attached to arabinofuran and...
6.
Jackson M, Crick D, Brennan P
J Biol Chem
. 2000 Jul;
275(39):30092-9.
PMID: 10889206
Phosphatidylinositol (PI) and metabolically derived products such as the phosphatidylinositol mannosides and linear and mature branched lipomannan and lipoarabinomannan are prominent phospholipids/lipoglycans of Mycobacterium sp. believed to play important roles...
7.
Schulbach M, Brennan P, Crick D
J Biol Chem
. 2000 May;
275(30):22876-81.
PMID: 10816587
We report the cloning, overexpression, and partial characterization of two unique Z-isoprenyl diphosphate synthase homologs from Mycobacterium tuberculosis. The first enzyme, Rv1086, adds one isoprene unit to omega,E-geranyl diphosphate. The...
8.
Andres D, Crick D, Finlin B, Waechter C
Methods Mol Biol
. 1999 Jul;
116:107-23.
PMID: 10399149
No abstract available.
9.
Crick D, Andres D, Danesi R, Macchia M, Waechter C
J Neurochem
. 1998 May;
70(6):2397-405.
PMID: 9603204
It is well documented that 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors prevent cultured mammalian cells from progressing through the cell cycle, suggesting a critical role for a mevalonate-derived product. Recently, it has been...
10.
Andres D, Shao H, Crick D, Finlin B
Arch Biochem Biophys
. 1997 Nov;
346(1):113-24.
PMID: 9328291
The CAAX farnesyltransferase is a heterodimeric enzyme that attaches a farnesyl group to a single cysteine in cellular proteins which terminate in the sequence CAAX, where C is cysteine, A...