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J S Rush

Explore the profile of J S Rush including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 38
Citations 439
Followers 0
Related Specialties
Biochemistry
Biophysics
Cell Biology
Top 10 Co-Authors
C J Waechter
R A Laine
S J Turco
E de Hoffmann
B A Wolucka
M Aebi
M A Lehrman
E C Snow
D C Crick
P D Hodgkin
Published In
Glycobiology
J Biol Chem
Arch Biochem Biophys
Anal Biochem
J Am Soc Mass Spectrom
Affiliations
Soon will be listed here.
Recent Articles
1.
A novel, blocking, Fc-silent anti-CD40 monoclonal antibody prolongs nonhuman primate renal allograft survival in the absence of B cell depletion
Cordoba F, Wieczorek G, Audet M, Roth L, Schneider M, Kunkler A, et al.
Am J Transplant . 2015 Jul; 15(11):2825-36. PMID: 26139432
CD40-CD154 pathway blockade prolongs renal allograft survival in nonhuman primates (NHPs). However, antibodies targeting CD154 were associated with an increased incidence of thromboembolic complications. Antibodies targeting CD40 prolong renal allograft...
2.
Determination of the anomeric configuration of glycosyl esters of nucleoside pyrophosphates and polyisoprenyl phosphates by fast-atom bombardment tandem mass spectrometry
Wolucka B, de Hoffmann E, Rush J, Waechter C
J Am Soc Mass Spectrom . 2013 Nov; 7(6):541-9. PMID: 24203426
Collision-induced dissociation of the deprotonated molecules of glycosyl esters of nucleoside pyrophosphates and polyisoprenyl (dolichyl and polyprenyl) phosphates results in distinct fragmentation patterns that depend on cis-trans configuration of the...
3.
The CWH8 gene encodes a dolichyl pyrophosphate phosphatase with a luminally oriented active site in the endoplasmic reticulum of Saccharomyces cerevisiae
Fernandez F, Rush J, Toke D, Han G, Quinn J, Carman G, et al.
J Biol Chem . 2001 Aug; 276(44):41455-64. PMID: 11504728
Mutations in the CWH8 gene, which encodes an ER transmembrane protein with a phosphate binding pocket in Saccharomyces cerevisiae, result in a deficiency in dolichyl pyrophosphate (Dol-P-P)-linked oligosaccharide intermediate synthesis...
4.
B cells activated via CD40 and IL-4 undergo a division burst but require continued stimulation to maintain division, survival and differentiation
Rush J, Hodgkin P
Eur J Immunol . 2001 Apr; 31(4):1150-9. PMID: 11298340
T cell stimulation of B cell proliferation during T-B collaboration requires membrane-bound stimulatory ligands, such as CD40 ligand and the secretion of soluble cytokines, such as IL-4. Nevertheless, it remains...
5.
An alternative cis-isoprenyltransferase activity in yeast that produces polyisoprenols with chain lengths similar to mammalian dolichols
Schenk B, Rush J, Waechter C, Aebi M
Glycobiology . 2001 Feb; 11(1):89-98. PMID: 11181565
Dolichyl monophosphate (Dol-P) is a polyisoprenoid glycosyl carrier lipid essential for the assembly of a variety of glycoconjugates in the endoplasmic reticulum of eukaryotic cells. In yeast, dolichols with chain...
6.
Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals
Anand M, Rush J, Ray S, Doucey M, Weik J, Ware F, et al.
Mol Biol Cell . 2001 Feb; 12(2):487-501. PMID: 11179430
The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such...
7.
Mannose supplementation corrects GDP-mannose deficiency in cultured fibroblasts from some patients with Congenital Disorders of Glycosylation (CDG)
Rush J, Panneerselvam K, Waechter C, Freeze H
Glycobiology . 2000 Aug; 10(8):829-35. PMID: 10929009
Congenital Disorders of Glycosylation (CDG) are human deficiencies in glycoprotein biosynthesis. Previous studies showed that 1 mM mannose corrects defective protein N-glycosylation in cultured fibroblasts from some CDG patients. We...
8.
Quantitative analysis of lymphocyte differentiation and proliferation in vitro using carboxyfluorescein diacetate succinimidyl ester
Hasbold J, Gett A, Rush J, Deenick E, Avery D, Jun J, et al.
Immunol Cell Biol . 1999 Nov; 77(6):516-22. PMID: 10571672
Mature T and B lymphocytes respond to receptor-delivered signals received during and following activation. These signals regulate the rates of cell death, growth, differentiation and migration that ultimately establish the...
9.
Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions
Thai L, Rush J, Maul J, Devarenne T, Rodgers D, Chappell J, et al.
Proc Natl Acad Sci U S A . 1999 Nov; 96(23):13080-5. PMID: 10557276
The ability of Nicotiana tabacum cell cultures to utilize farnesol (F-OH) for sterol and sesquiterpene biosynthesis was investigated. [(3)H]F-OH was readily incorporated into sterols by rapidly growing cell cultures. However,...
10.
Topological studies on the enzymes catalyzing the biosynthesis of Glc-P-dolichol and the triglucosyl cap of Glc3Man9GlcNAc2-P-P-dolichol in microsomal vesicles from pig brain: use of the processing glucosidases I/II as latency markers
Rush J, Waechter C
Glycobiology . 1998 Dec; 8(12):1207-13. PMID: 9858642
In the current model for Glc3Man9GlcNAc2-P-P-Dol assembly, Man5GlcNAc2-P-P-Dol, Man-P-Dol, and Glc-P-Dol are synthesized on the cytoplasmic face of the ER and diffuse transversely to the lumenal leaflet where the synthesis...