Comparison of the UDP-N-acetylmuramate:L-alanine Ligase Enzymes from Mycobacterium Tuberculosis and Mycobacterium Leprae

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2000 Nov 14

PMID 11073931

Citations 29

Authors

S Mahapatra

D C Crick

P J Brennan

Affiliations

Soon will be listed here.

Abstract

In the peptidoglycan of Mycobacterium leprae, L-alanine of the side chain is replaced by glycine. When expressed in Escherichia coli, MurC (UDP-N-acetyl-muramate:L-alanine ligase) of M. leprae showed K(m) and V(max) for L-alanine and glycine similar to those of Mycobacterium tuberculosis MurC, suggesting that another explanation should be sought for the presence of glycine.

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