Curtis J Henry
Overview
Explore the profile of Curtis J Henry including associated specialties, affiliations and a list of published articles.
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32
Citations
554
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Recent Articles
1.
Townsel A, Jaffe M, Wu Y, Henry C, Haynes K
Adv Exp Med Biol
. 2024 Nov;
1465:37-53.
PMID: 39586992
Obesity is a risk factor for developing breast cancer, and significantly increases mortality rates in patients diagnosed with this disease. Drivers of this unfortunate relationships are multifactorial, with obesity-induced changes...
2.
Huelse J, Bhasin S, Jacobsen K, Yim J, Thomas B, Branella G, et al.
Leukemia
. 2024 Sep;
38(12):2685-2698.
PMID: 39322710
TAM-family tyrosine kinases (TYRO3, AXL and MERTK) are potential cancer therapeutic targets. In previous studies MERTK inhibition in the immune microenvironment was therapeutically effective in a B-cell acute leukemia (B-ALL)...
3.
Zhu Y, Banerjee A, Xie P, Ivanov A, Uddin A, Jiao Q, et al.
J Clin Invest
. 2024 Mar;
134(10).
PMID: 38530357
Despite widespread utilization of immunotherapy, treating immune-cold tumors remains a challenge. Multiomic analyses and experimental validation identified the OTUD4/CD73 proteolytic axis as a promising target in treating immune-suppressive triple negative...
4.
The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces
Kellner A, Hunter R, Do P, Eggert J, Jaffe M, Geitgey D, et al.
bioRxiv
. 2024 Feb;
PMID: 38352441
Obesity is a major public health crisis given its rampant growth and association with an increased risk for cancer. Interestingly, patients with obesity tend to have an increased tumor burden...
5.
Shim J, Park S, Venkateswaran S, Kumar D, Prince C, Parihar V, et al.
Blood
. 2023 Aug;
142(23):1972-1984.
PMID: 37624902
Hemophagocytic lymphohistiocytosis (HLH) is characterized by hyperinflammation and multiorgan dysfunction. Infections, including the reactivation of viruses, contribute to significant disease mortality in HLH. Although T-cell and natural killer cell-driven immune...
6.
Pillsbury C, Dougan J, Rabe J, Fonseca J, Zhou C, Evans A, et al.
Cancer Res Commun
. 2023 Jul;
3(7):1248-1259.
PMID: 37465593
Significance: We demonstrate that Sig15 is overexpressed in hematologic malignancies driven by NFκB, is required for immune evasion in a mouse model of leukemia, and, for the first time, that...
7.
8.
Cash T, Jonus H, Tsvetkova M, Beumer J, Sadanand A, Lee J, et al.
Pediatr Blood Cancer
. 2023 May;
70(8):e30405.
PMID: 37158620
Background: 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can inhibit tumor proliferation, angiogenesis, and restore apoptosis in preclinical pediatric solid tumor models. We conducted a phase 1 trial to determine the...
9.
Geitgey D, Lee M, Cottrill K, Jaffe M, Pilcher W, Bhasin S, et al.
J Natl Cancer Inst Monogr
. 2023 May;
2023(61):12-29.
PMID: 37139973
The obesity pandemic currently affects more than 70 million Americans and more than 650 million individuals worldwide. In addition to increasing susceptibility to pathogenic infections (eg, SARS-CoV-2), obesity promotes the...
10.
Birnbaum L, Sullivan E, Do P, Uricoli B, Raikar S, Porter C, et al.
Biomacromolecules
. 2023 Feb;
24(3):1164-1172.
PMID: 36745712
Cytokines act as potent, extracellular signals of the human immune system and can elicit striking treatment responses in patients with autoimmune disease, tissue damage, and cancer. Yet, despite their therapeutic...