Craig Dorrell
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Explore the profile of Craig Dorrell including associated specialties, affiliations and a list of published articles.
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37
Citations
3428
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Recent Articles
11.
Furuyama K, Chera S, van Gurp L, Oropeza D, Ghila L, Damond N, et al.
Nature
. 2019 Feb;
567(7746):43-48.
PMID: 30760930
Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In...
12.
Li B, Dorrell C, Canady P, Wakefield L
Methods Mol Biol
. 2018 Dec;
1905:19-27.
PMID: 30536087
Cholangiocytes are proliferative and are one of the sources for liver progenitor cells. Clonogenic cholangiocytes are defined as cells capable of clonally proliferating and differentiating cholangiocytes both in vitro and...
13.
Benninger R, Dorrell C, Hodson D, Rutter G
Curr Diab Rep
. 2018 Sep;
18(11):112.
PMID: 30251179
Purpose Of Review: To discuss advances in our understanding of beta-cell heterogeneity and the ramifications of this for type 1 diabetes (T1D) and its therapy. Recent Findings: A number of...
14.
Wang Y, Dorrell C, Naugler W, Heskett M, Spellman P, Li B, et al.
Mol Ther
. 2018 Mar;
26(5):1327-1342.
PMID: 29550076
Direct lineage reprogramming can convert readily available cells in the body into desired cell types for cell replacement therapy. This is usually achieved through forced activation or repression of lineage-defining...
15.
Jakel C, Bergmann F, Toth R, Assenov Y, van der Duin D, Strobel O, et al.
Nat Commun
. 2017 Nov;
8(1):1323.
PMID: 29109526
Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The...
16.
Cogger K, Sinha A, Sarangi F, McGaugh E, Saunders D, Dorrell C, et al.
Nat Commun
. 2017 Aug;
8(1):331.
PMID: 28835709
PDX1/NKX6-1 pancreatic progenitors (PPs) give rise to endocrine cells both in vitro and in vivo. This cell population can be successfully differentiated from human pluripotent stem cells (hPSCs) and hold...
17.
Li B, Dorrell C, Canaday P, Pelz C, Haft A, Finegold M, et al.
Stem Cell Reports
. 2017 Jul;
9(2):478-489.
PMID: 28689996
The biliary system plays an important role in several acquired and genetic disorders of the liver. We have previously shown that biliary duct epithelium contains cells giving rise to proliferative...
18.
Yang C, Galivo F, Dorrell C
Curr Opin Endocrinol Diabetes Obes
. 2017 Jan;
24(2):92-97.
PMID: 28099206
Purpose Of Review: This report examines recent publications identifying phenotypic and functional heterogeneity among pancreatic β cells and investigating their potential roles in normal and abnormal islet function. The development...
19.
Wang Y, Golson M, Schug J, Traum D, Liu C, Vivek K, et al.
Cell Metab
. 2016 Oct;
24(4):616-626.
PMID: 27732837
The human endocrine pancreas consists of multiple cell types and plays a critical role in glucose homeostasis. Here, we apply mass cytometry technology to measure all major islet hormones, proliferative...
20.
Dorrell C, Schug J, Canaday P, Russ H, Tarlow B, Grompe M, et al.
Nat Commun
. 2016 Jul;
7:11756.
PMID: 27399229
Human pancreatic islets of Langerhans contain five distinct endocrine cell types, each producing a characteristic hormone. The dysfunction or loss of the insulin-producing β cells causes diabetes mellitus, a disease...