Craig Dorrell
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Explore the profile of Craig Dorrell including associated specialties, affiliations and a list of published articles.
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37
Citations
3428
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Recent Articles
1.
Dorrell C, Peters A, Zhang Q, Balaji N, Baradar K, Mochizuki-Kashio M, et al.
Pediatr Blood Cancer
. 2024 May;
71(8):e31030.
PMID: 38733122
Fanconi anemia (FA) is a disease caused by defective deoxyribonucleic acid (DNA) repair that manifests as bone marrow failure, cancer predisposition, and developmental defects. We previously reported that monotherapy with...
2.
Tiyaboonchai A, Wakefield L, Vonada A, May C, Dorrell C, Enicks D, et al.
Dev Biol
. 2023 Oct;
504:120-127.
PMID: 37813160
The current gold-standard for genetic lineage tracing in transgenic mice is based on cell-type specific expression of Cre recombinase. As an alternative, we developed a cell-type specific CRISPR/spCas9 system for...
3.
Dorrell C, Peters A, Zhang Q, Balaji N, Baradar K, Mochizuki-Kashio M, et al.
bioRxiv
. 2023 Aug;
PMID: 37649908
Fanconi Anemia (FA) is a disease caused by defective DNA repair which manifests as bone marrow failure, cancer predisposition, and developmental defects. Mice containing inactivating mutations in one or more...
4.
Moser R, Annis J, Nikolova O, Whatcott C, Gurley K, Mendez E, et al.
Cancer Res
. 2022 Jul;
82(18):3375-3393.
PMID: 35819261
Pancreatic ductal adenocarcinoma (PDAC) typically presents as metastatic disease at diagnosis and remains refractory to treatment. Next-generation sequencing efforts have described the genomic landscape, classified molecular subtypes, and confirmed frequent...
5.
Shah V, Dorrell C, Al-Fatease A, Allen-Petersen B, Woo Y, Bortnyak Y, et al.
Pharmaceutics
. 2022 Apr;
14(4).
PMID: 35456547
Pancreatic ductal adenocarcinoma (PDAC) presents as an unmet clinical challenge for drug delivery due to its unique hypoxic biology. Vinblastine-N-Oxide (CPD100) is a hypoxia-activated prodrug (HAP) that selectively converts to...
6.
Chai S, Kim Y, Galivo F, Dorrell C, Wakefield L, Posey J, et al.
Hum Gene Ther
. 2022 Mar;
33(15-16):789-800.
PMID: 35297680
Diabetes mellitus, caused by loss or dysfunction of the insulin-producing beta cells of the pancreas, is a promising target for recombinant adeno-associated virus (rAAV)-mediated gene therapy. To target potential therapeutic...
7.
Buenafe A, Dorrell C, Reddy A, Klimek J, Marks D
Sci Rep
. 2022 Mar;
12(1):3556.
PMID: 35241737
Extracellular vesicles (EVs) are produced and released by both healthy and malignant cells and bear markers indicative of ongoing biological processes. In the present study we utilized high resolution flow...
8.
Ogawa M, Jiang J, Xia S, Yang D, Ding A, Laselva O, et al.
Nat Commun
. 2021 Nov;
12(1):6504.
PMID: 34764255
The derivation of mature functional cholangiocytes from human pluripotent stem cells (hPSCs) provides a model for studying the pathogenesis of cholangiopathies and for developing therapies to treat them. Current differentiation...
9.
Liu W, Kin T, Ho S, Dorrell C, Campbell S, Luo P, et al.
EBioMedicine
. 2019 Nov;
50:306-316.
PMID: 31780397
Background: The understanding of the regulation of glucagon secretion by pancreatic islet α-cells remains elusive. We aimed to develop an in vitro model for investigating the function of human α-cells...
10.
Auciello F, Bulusu V, Oon C, Tait-Mulder J, Berry M, Bhattacharyya S, et al.
Cancer Discov
. 2019 Mar;
9(5):617-627.
PMID: 30837243
Pancreatic ductal adenocarcinoma (PDAC) develops a pronounced stromal response reflecting an aberrant wound-healing process. This stromal reaction features transdifferentiation of tissue-resident pancreatic stellate cells (PSC) into activated cancer-associated fibroblasts, a...