Congrong Niu
Overview
Explore the profile of Congrong Niu including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1547
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Recent Articles
1.
Niu C, Xie X, Liu R, Liang X, Hu Y, Lai Y
Drug Metab Dispos
. 2024 Mar;
52(5):432-441.
PMID: 38485279
Drug-induced liver injury (DILI) is a frequent cause of clinical trial failures during drug development. While inhibiting bile salt export pump (BSEP) is a well-documented DILI mechanism, interference with genes...
2.
Burdette D, Hyrina A, Song Z, Beran R, Cheung T, Gilmore S, et al.
Antimicrob Agents Chemother
. 2022 Dec;
67(1):e0134822.
PMID: 36519892
The standard of care for the treatment of chronic hepatitis B (CHB) is typically lifelong treatment with nucleos(t)ide analogs (NAs), which suppress viral replication and provide long-term clinical benefits. However,...
3.
Vermillion M, Murakami E, Ma B, Pitts J, Tomkinson A, Rautiola D, et al.
Sci Transl Med
. 2021 Dec;
14(633):eabl8282.
PMID: 34968150
Remdesivir (RDV) is a nucleotide analog prodrug with demonstrated clinical benefit in patients with coronavirus disease 2019 (COVID-19). In October 2020, the US FDA approved intravenous (IV) RDV as the...
4.
Li R, Liclican A, Xu Y, Pitts J, Niu C, Zhang J, et al.
Antimicrob Agents Chemother
. 2021 Jun;
65(9):e0060221.
PMID: 34125594
Remdesivir (RDV; GS-5734, Veklury), the first FDA-approved antiviral to treat COVID-19, is a single-diastereomer monophosphoramidate prodrug of an adenosine analogue. RDV is taken up in the target cells and metabolized...
5.
Cheng Y, Liang X, Hao J, Niu C, Lai Y
Clin Transl Sci
. 2021 May;
14(5):1924-1934.
PMID: 34058067
The impact of organic anion-transporting polypeptide (OATP) inhibition on systemic and liver exposures of three OATP substrates was investigated in cynomolgus monkeys. A monkey physiologically-based pharmacokinetic (PBPK) model was constructed...
6.
Niu C, Smith B, Lai Y
Front Pharmacol
. 2021 Feb;
11:620197.
PMID: 33551819
The induction potentials of ligand-activated nuclear receptors on metabolizing enzyme genes are routinely tested for new chemical entities. However, regulations of drug transporter genes by the nuclear receptor ligands are...
7.
Liang X, Park Y, DeForest N, Hao J, Zhao X, Niu C, et al.
Drug Metab Dispos
. 2020 Oct;
48(12):1283-1292.
PMID: 33037043
It is well documented that human hepatic clearance based on in vitro metabolism or transporter assays systematically resulted in underprediction; therefore, large empirical scalars are often needed in either static...
8.
Mackman R, Mish M, Chin G, Perry J, Appleby T, Aktoudianakis V, et al.
J Med Chem
. 2020 May;
63(18):10188-10203.
PMID: 32407112
Toll-like receptor 8 (TLR8) recognizes pathogen-derived single-stranded RNA fragments to trigger innate and adaptive immune responses. Chronic hepatitis B (CHB) is associated with a dysfunctional immune response, and therefore a...
9.
Wang T, Babusis D, Park Y, Niu C, Kim C, Zhao X, et al.
Drug Metab Pharmacokinet
. 2020 Apr;
35(3):334-340.
PMID: 32345577
Sofosbuvir (SOF) is a nucleotide prodrug which has been used as a backbone for the clinical treatment of hepatitis C viral infection. Because sofosbuvir undergoes complex first pass metabolism, including...
10.
Niu C, Wang Y, Zhao X, Tep S, Murakami E, Subramanian R, et al.
Drug Metab Dispos
. 2019 Oct;
47(12):1433-1442.
PMID: 31582395
Induction potentials of the pregnane X receptor (PXR) activator rifampin (RIF) on transporter genes [e.g., organic anion-transporting polypeptides (OATPs)] are still in its infancy or remain controversial in the field....