Collin Y Ewald
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Explore the profile of Collin Y Ewald including associated specialties, affiliations and a list of published articles.
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59
Citations
982
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Recent Articles
1.
Martinovic A, Mantovani M, Trpchevska N, Novak E, Milev N, Bode L, et al.
Front Aging
. 2024 Dec;
5:1495029.
PMID: 39659760
Longevity medicine is an emerging and iterative healthcare discipline focusing on early detection, preventive measures, and personalized approaches that aim to extend healthy lifespan and promote healthy aging. This comprehensive...
2.
Lyu Y, Fu Q, Wilczok D, Ying K, King A, Antebi A, et al.
Aging (Albany NY)
. 2024 Oct;
16(20):12955-12976.
PMID: 39418098
The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We,...
3.
Das M, Semple J, Haemmerli A, Volodkina V, Scotton J, Gitchev T, et al.
Nat Genet
. 2024 Jul;
56(8):1737-1749.
PMID: 39039278
The structural maintenance of chromosome (SMC) complexes-cohesin and condensins-are crucial for chromosome separation and compaction during cell division. During the interphase, mammalian cohesins additionally fold the genome into loops and...
4.
Jongsma E, Grigolon G, Baumann J, Weinkove D, Ewald C, Wandrey F, et al.
Nutrients
. 2024 Jul;
16(13).
PMID: 38999870
Investigations into human longevity are increasingly focusing on healthspan enhancement, not just lifespan extension. Lifestyle modifications and nutritional choices, including food supplements, can significantly affect aging and general health. Phytochemicals...
5.
Ravanelli S, Park J, Wicky C, Ewald C, von Meyenn F
MicroPubl Biol
. 2024 Jul;
2024.
PMID: 38947245
The intersection of metabolic processes and epigenetic regulation during embryogenesis is crucial yet not fully understood. Through a candidate RNAi screen in , we identified metabolic enzymes ALDO-2 and PDHB-1...
6.
Moliere A, Park J, Goyala A, Vayndorf E, Zhang B, Hsiung K, et al.
Geroscience
. 2024 Jun;
46(5):5015-5036.
PMID: 38900346
Little is known about the possibility of reversing age-related biological changes when they have already occurred. To explore this, we have characterized the effects of reducing insulin/IGF-1 signaling (IIS) during...
7.
Ewald C, Pulous F, Lok S, Pun F, Aliper A, Ren F, et al.
Trends Pharmacol Sci
. 2024 May;
45(6):478-489.
PMID: 38777670
Traf2- and Nck-interacting kinase (TNIK) has emerged as a key regulator of pathological metabolic signaling in several diseases and is a promising drug target. Originally studied for its role in...
8.
Doleckova I, Vidovic T, Jandova L, Gretzmeier C, Navarini A, MacArthur M, et al.
J Invest Dermatol
. 2024 Mar;
144(9):2103-2107.e2.
PMID: 38490440
No abstract available.
9.
Sharma A, Ewald C
MicroPubl Biol
. 2024 Jan;
2024.
PMID: 38287930
Numerous anti-amyloid therapies have seen recent clinical development and approval, such as the monoclonal antibodies aducanumab and lecanemab. However, in Alzheimer's disease patients, amyloid-β (Aβ) plaques are found embedded in...
10.
Teuscher A, Statzer C, Goyala A, Domenig S, Schoen I, Hess M, et al.
Nat Commun
. 2024 Jan;
15(1):276.
PMID: 38177158
Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role of ECM...