Colin Macaulay
Overview
Explore the profile of Colin Macaulay including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
222
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Recent Articles
1.
Lucas A, Yaron J, Zhang L, Macaulay C, McFadden G
Methods Mol Biol
. 2018 Sep;
1826:255-265.
PMID: 30194606
Serine protease inhibitors, or serpins, function as central regulators for many vital processes in the mammalian body, maintaining homeostasis for clot formation and breakdown, immune responses, lung function, and hormone...
2.
Mahon B, Ambadapadi S, Yaron J, Lomelino C, Pinard M, Keinan S, et al.
Biochemistry
. 2017 Dec;
57(7):1096-1107.
PMID: 29227673
The Myxomavirus-derived protein Serp-1 has potent anti-inflammatory activity in models of vasculitis, lupus, viral sepsis, and transplant. Serp-1 has also been tested successfully in a Phase IIa clinical trial in...
3.
Chen H, Zheng D, Ambadapadi S, Davids J, Ryden S, Samy H, et al.
PLoS One
. 2015 Feb;
10(2):e0115482.
PMID: 25658487
Giant cell arteritis (GCA) and Takayasu's disease are inflammatory vasculitic syndromes (IVS) causing sudden blindness and widespread arterial obstruction and aneurysm formation. Glucocorticoids and aspirin are mainstays of treatment, predominantly...
4.
Brahn E, Lee S, Lucas A, McFadden G, Macaulay C
Clin Immunol
. 2014 May;
153(2):254-63.
PMID: 24845791
Many viruses encode virulence factors to facilitate their own survival by modulating a host's inflammatory response. One of these factors, secreted from cells infected with myxoma virus, is the serine...
5.
Chen H, Zheng D, Abbott J, Liu L, Bartee M, Long M, et al.
Antimicrob Agents Chemother
. 2013 Jun;
57(9):4114-27.
PMID: 23774438
Lethal viral infections produce widespread inflammation with vascular leak, clotting, and bleeding (disseminated intravascular coagulation [DIC]), organ failure, and high mortality. Serine proteases in clot-forming (thrombotic) and clot-dissolving (thrombolytic) cascades...
6.
Chen H, Zheng D, Davids J, Bartee M, Dai E, Liu L, et al.
Methods Enzymol
. 2011 Jun;
499:301-29.
PMID: 21683260
Over the past 19 years, we have developed a novel myxoma virus-derived anti-inflammatory serine protease inhibitor, termed a serpin, as a new class of immunomodulatory therapeutic. This review will describe...
7.
Tardif J, LAllier P, Gregoire J, Ibrahim R, McFadden G, Kostuk W, et al.
Circ Cardiovasc Interv
. 2010 Nov;
3(6):543-8.
PMID: 21062996
Background: Vascular inflammation can lead to plaque instability and acute coronary syndromes (ACS). Viruses produce potent immunomodulating proteins that regulate key inflammatory pathways. A myxoma virus-derived serpin Serp-1 reduces inflammatory...
8.
Dai E, Liu L, Wang H, McIvor D, Sun Y, Macaulay C, et al.
PLoS One
. 2010 May;
5(5):e10510.
PMID: 20463901
Background: Binding of chemokines to glycosaminoglycans (GAGs) is classically described as initiating inflammatory cell migration and creating tissue chemokine gradients that direct local leukocyte chemotaxis into damaged or transplanted tissues....
9.
Lucas A, Liu L, Dai E, Bot I, Viswanathan K, Munuswamy-Ramunujam G, et al.
Adv Exp Med Biol
. 2010 Jan;
666:132-56.
PMID: 20054981
Serine proteinase inhibitors, also called serpins, are an ancient grouping of proteins found in primitive organisms from bacteria, protozoa and horseshoe crabs and thus likely present at the time of...
10.
Bartee M, Dai E, Liu L, Munuswamy-Ramanujam G, Macaulay C, McIvor D, et al.
Methods Enzymol
. 2009 May;
460:209-28.
PMID: 19446727
Chemokines are important for activation of a host of cellular immune and inflammatory responses including cell signaling, activation, and communication. M-T7, a myxoma virus protein, inhibits the activity of chemokines...