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Clinton T Baldwin

Explore the profile of Clinton T Baldwin including associated specialties, affiliations and a list of published articles. Areas
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Articles 71
Citations 6432
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Recent Articles
1.
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, et al.
medRxiv . 2023 Jul; PMID: 37461624
Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset...
2.
Kunkle B, Grenier-Boley B, Sims R, Bis J, Damotte V, Naj A, et al.
Nat Genet . 2019 Aug; 51(9):1423-1424. PMID: 31417202
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
3.
Kunkle B, Grenier-Boley B, Sims R, Bis J, Damotte V, Naj A, et al.
Nat Genet . 2019 Mar; 51(3):414-430. PMID: 30820047
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed...
4.
Sims R, van der Lee S, Naj A, Bellenguez C, Badarinarayan N, Jakobsdottir J, et al.
Nat Genet . 2017 Jul; 49(9):1373-1384. PMID: 28714976
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage...
5.
Ghani M, Reitz C, Cheng R, Vardarajan B, Jun G, Sato C, et al.
JAMA Neurol . 2015 Sep; 72(11):1313-23. PMID: 26366463
Importance: Mutations in known causal Alzheimer disease (AD) genes account for only 1% to 3% of patients and almost all are dominantly inherited. Recessive inheritance of complex phenotypes can be...
6.
Hohman T, Cooke-Bailey J, Reitz C, Jun G, Naj A, Beecham G, et al.
Alzheimers Dement . 2015 Jun; 12(3):233-43. PMID: 26092349
Introduction: African-American (AA) individuals have a higher risk for late-onset Alzheimer's disease (LOAD) than Americans of primarily European ancestry (EA). Recently, the largest genome-wide association study in AAs to date...
7.
Nho K, Kim S, Risacher S, Shen L, Corneveaux J, Swaminathan S, et al.
Ann Neurol . 2015 Jan; 77(3):547-52. PMID: 25559091
We used whole-exome sequencing to identify variants other than APOE associated with the rate of hippocampal atrophy in amnestic mild cognitive impairment. An in-silico predicted missense variant in REST (rs3796529)...
8.
Wang L, Naj A, Graham R, Crane P, Kunkle B, Cruchaga C, et al.
JAMA Neurol . 2014 Dec; 72(2):209-16. PMID: 25531812
Importance: Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position...
9.
Sikora J, Logue M, Chan G, Spencer B, Prokaeva T, Baldwin C, et al.
Hum Genet . 2014 Nov; 134(1):111-21. PMID: 25367359
Wild-type transthyretin amyloidosis (ATTRwt), typically diagnosed as congestive heart failure in elderly Caucasian men, features myocardial amyloid deposits of wild-type plasma protein transthyretin (TTR). ATTRwt is sporadic, its pathogenesis is...
10.
Naj A, Jun G, Reitz C, Kunkle B, Perry W, Park Y, et al.
JAMA Neurol . 2014 Sep; 71(11):1394-404. PMID: 25199842
Importance: Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD...