Kathryn L Lunetta
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Explore the profile of Kathryn L Lunetta including associated specialties, affiliations and a list of published articles.
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258
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19080
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Recent Articles
1.
Choi S, Jurgens S, Xiao L, Hill M, Haggerty C, Sveinbjornsson G, et al.
Nat Genet
. 2025 Mar;
57(3):548-562.
PMID: 40050430
Atrial fibrillation (AF) is a prevalent and morbid abnormality of the heart rhythm with a strong genetic component. Here, we meta-analyzed genome and exome sequencing data from 36 studies that...
2.
Roselli C, Surakka I, S Olesen M, Sveinbjornsson G, Marston N, Choi S, et al.
Nat Genet
. 2025 Mar;
57(3):539-547.
PMID: 40050429
Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power...
3.
Kang M, Ang T, Devine S, Sherva R, Mukherjee S, Trittschuh E, et al.
medRxiv
. 2025 Feb;
PMID: 39990565
Background: Genome-wide association studies (GWAS) have identified over 1,000 blood pressure (BP) loci and over 80 loci for Alzheimer's disease (AD). Considering BP is an AD risk factor, identifying pleiotropy...
4.
Sheehy S, Friedman D, Liu C, Lunetta K, Zirpoli G, Palmer J
Eur J Obstet Gynecol Reprod Biol X
. 2025 Feb;
25:100365.
PMID: 39895997
Background: Preeclampsia and preterm birth disproportionally affects Black women, but the current understanding of genetic predisposition to preeclampsia and preterm birth is rudimentary. It has been hypothesized that carriers of...
5.
Predicting Atrial Fibrillation After Stroke by Combining Polygenic Risk Scores and Clinical Features
Tack R, Tan B, Senff J, Prapiadou S, Kimball T, Khurshid S, et al.
Stroke
. 2025 Jan;
PMID: 39882610
Since treatment with anticoagulants can prevent recurrent strokes, identification of patients at risk for incident AF after stroke is crucial. We aimed to investigate whether the addition of AF polygenic...
6.
Weng L, Ramo J, Jurgens S, Khurshid S, Chaffin M, Hall A, et al.
Nat Genet
. 2025 Jan;
57(1):53-64.
PMID: 39747593
To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals...
7.
Chen J, Murabito J, Lunetta K
Brief Bioinform
. 2024 Nov;
26(1).
PMID: 39581869
The Gaussian graphical model (GGM) is a statistical network approach that represents conditional dependencies among components, enabling a comprehensive exploration of disease mechanisms using high-throughput multi-omics data. Analyzing differential and...
8.
Tong T, Zhu C, Farrell J, Khurshid Z, Martin E, Pericak-Vance M, et al.
Alzheimers Res Ther
. 2024 Oct;
16(1):234.
PMID: 39444005
Background: Blood-derived mitochondrial DNA copy number (mtDNA-CN) is a proxy measurement of mitochondrial function in the peripheral and central systems. Abnormal mtDNA-CN not only indicates impaired mtDNA replication and transcription...
9.
Gunn S, Wang X, Posner D, Cho K, Huffman J, Gaziano M, et al.
HGG Adv
. 2024 Sep;
6(1):100355.
PMID: 39323095
Polygenic scores (PGSs) are a promising tool for estimating individual-level genetic risk of disease based on the results of genome-wide association studies (GWASs). However, their promise has yet to be...
10.
Chen J, Ragab A, Doyle M, Alosco M, Fang Y, Mez J, et al.
Alzheimers Dement
. 2024 Sep;
20(11):7465-7478.
PMID: 39282876
Introduction: Brain magnetic resonance imaging (MRI) and inflammatory biomarkers are crucial for investigating preclinical neurocognitive disorders. Current investigations focus on a few inflammatory markers. The study aims to investigate the...